Cancer and ageing: convergent and divergent mechanisms

被引：144

作者：

Serrano, Manuel ^{[1
]}

Blasco, Maria A. ^{[1
]}

机构：

[1] Spanish Natl Canc Res Ctr, E-28029 Madrid, Spain

来源：

NATURE REVIEWS MOLECULAR CELL BIOLOGY | 2007年 / 8卷 / 09期

关键词：

D O I：

10.1038/nrm2242

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 [细胞生物学]; 090102 [作物遗传育种];

摘要：

Cancer and ageing are both fuelled by the accumulation of cellular damage. Consequently, those mechanisms that protect cells from damage simultaneously provide protection against cancer and ageing. By contrast, cancer and longevity require a durable cell proliferation potential and, therefore, those mechanisms that limit indefinite proliferation provide cancer protection but favour ageing. The overall balance between these convergent and divergent mechanisms guarantees fitness and a cancer-free life until late adulthood for most individuals.

引用

收藏

页码：715 / 722

页数：8

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