共 110 条
Telomeres and human disease: Ageing, cancer and beyond
被引:1248
作者:

Blasco, MA
论文数: 0 引用数: 0
h-index: 0
机构:
Spanish Natl Canc Ctr CNIO, Telomeres & Telomerase Grp, Mol Oncol Program, Madrid 28029, Spain Spanish Natl Canc Ctr CNIO, Telomeres & Telomerase Grp, Mol Oncol Program, Madrid 28029, Spain
机构:
[1] Spanish Natl Canc Ctr CNIO, Telomeres & Telomerase Grp, Mol Oncol Program, Madrid 28029, Spain
关键词:
D O I:
10.1038/nrg1656
中图分类号:
Q3 [遗传学];
学科分类号:
071007 ;
090102 ;
摘要:
Telomere length and telomerase activity are important factors in the pathobiology of human disease. Age-related diseases and premature ageing syndromes are characterized by short telomeres, which can compromise cell viability, whereas tumour cells can prevent telomere loss by aberrantly upregulating telomerase. Altered functioning of both telomerase and telomere-interacting proteins is present in some human premature ageing syndromes and in cancer, and recent findings indicate that alterations that affect telomeres at the level of chromatin structure might also have a role in human disease. These findings have inspired a number of potential therapeutic strategies that are based on telomerase and telomeres.
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页码:611 / 622
页数:12
相关论文
共 110 条
[1]
Epigenetic consequences of nucleosome dynamics
[J].
Ahmad, K
;
Henikoff, S
.
CELL,
2002, 111 (03)
:281-284

Ahmad, K
论文数: 0 引用数: 0
h-index: 0
机构:
Fred Hutchinson Canc Res Ctr, Seattle, WA 98109 USA Fred Hutchinson Canc Res Ctr, Seattle, WA 98109 USA

Henikoff, S
论文数: 0 引用数: 0
h-index: 0
机构:
Fred Hutchinson Canc Res Ctr, Seattle, WA 98109 USA Fred Hutchinson Canc Res Ctr, Seattle, WA 98109 USA
[2]
Constitutive telomerase expression promotes mammary carcinomas in aging mice
[J].
Artandi, SE
;
Alson, S
;
Tietze, MK
;
Sharpless, NE
;
Ye, S
;
Greenberg, RA
;
Castrillon, DH
;
Horner, JW
;
Weiler, SR
;
Carrasco, RD
;
DePinho, RA
.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA,
2002, 99 (12)
:8191-8196

Artandi, SE
论文数: 0 引用数: 0
h-index: 0
机构: Harvard Univ, Sch Med, Dana Farber Canc Inst, Dept Adult Oncol, Boston, MA 02115 USA

Alson, S
论文数: 0 引用数: 0
h-index: 0
机构: Harvard Univ, Sch Med, Dana Farber Canc Inst, Dept Adult Oncol, Boston, MA 02115 USA

Tietze, MK
论文数: 0 引用数: 0
h-index: 0
机构: Harvard Univ, Sch Med, Dana Farber Canc Inst, Dept Adult Oncol, Boston, MA 02115 USA

Sharpless, NE
论文数: 0 引用数: 0
h-index: 0
机构: Harvard Univ, Sch Med, Dana Farber Canc Inst, Dept Adult Oncol, Boston, MA 02115 USA

Ye, S
论文数: 0 引用数: 0
h-index: 0
机构: Harvard Univ, Sch Med, Dana Farber Canc Inst, Dept Adult Oncol, Boston, MA 02115 USA

Greenberg, RA
论文数: 0 引用数: 0
h-index: 0
机构: Harvard Univ, Sch Med, Dana Farber Canc Inst, Dept Adult Oncol, Boston, MA 02115 USA

Castrillon, DH
论文数: 0 引用数: 0
h-index: 0
机构: Harvard Univ, Sch Med, Dana Farber Canc Inst, Dept Adult Oncol, Boston, MA 02115 USA

Horner, JW
论文数: 0 引用数: 0
h-index: 0
机构: Harvard Univ, Sch Med, Dana Farber Canc Inst, Dept Adult Oncol, Boston, MA 02115 USA

Weiler, SR
论文数: 0 引用数: 0
h-index: 0
机构: Harvard Univ, Sch Med, Dana Farber Canc Inst, Dept Adult Oncol, Boston, MA 02115 USA

Carrasco, RD
论文数: 0 引用数: 0
h-index: 0
机构: Harvard Univ, Sch Med, Dana Farber Canc Inst, Dept Adult Oncol, Boston, MA 02115 USA

DePinho, RA
论文数: 0 引用数: 0
h-index: 0
机构: Harvard Univ, Sch Med, Dana Farber Canc Inst, Dept Adult Oncol, Boston, MA 02115 USA
[3]
Strand-specific postreplicative processing of mammalian telomeres
[J].
Bailey, SM
;
Cornforth, MN
;
Kurimasa, A
;
Chen, DJ
;
Goodwin, EH
.
SCIENCE,
2001, 293 (5539)
:2462-2465

Bailey, SM
论文数: 0 引用数: 0
h-index: 0
机构: Los Alamos Natl Lab, Biosci Div, Los Alamos, NM 87544 USA

Cornforth, MN
论文数: 0 引用数: 0
h-index: 0
机构: Los Alamos Natl Lab, Biosci Div, Los Alamos, NM 87544 USA

Kurimasa, A
论文数: 0 引用数: 0
h-index: 0
机构: Los Alamos Natl Lab, Biosci Div, Los Alamos, NM 87544 USA

Chen, DJ
论文数: 0 引用数: 0
h-index: 0
机构: Los Alamos Natl Lab, Biosci Div, Los Alamos, NM 87544 USA

Goodwin, EH
论文数: 0 引用数: 0
h-index: 0
机构: Los Alamos Natl Lab, Biosci Div, Los Alamos, NM 87544 USA
[4]
Atm-deficient mice: A paradigm of ataxia telangiectasia
[J].
Barlow, C
;
Hirotsune, S
;
Paylor, R
;
Liyanage, M
;
Eckhaus, M
;
Collins, F
;
Shiloh, Y
;
Crawley, JN
;
Ried, T
;
Tagle, D
;
WynshawBoris, A
.
CELL,
1996, 86 (01)
:159-171

Barlow, C
论文数: 0 引用数: 0
h-index: 0
机构: NATL INST HLTH,NATL CTR HUMAN GENOME RES,LAB GENE TRANSFER,BETHESDA,MD 20892

Hirotsune, S
论文数: 0 引用数: 0
h-index: 0
机构: NATL INST HLTH,NATL CTR HUMAN GENOME RES,LAB GENE TRANSFER,BETHESDA,MD 20892

Paylor, R
论文数: 0 引用数: 0
h-index: 0
机构: NATL INST HLTH,NATL CTR HUMAN GENOME RES,LAB GENE TRANSFER,BETHESDA,MD 20892

Liyanage, M
论文数: 0 引用数: 0
h-index: 0
机构: NATL INST HLTH,NATL CTR HUMAN GENOME RES,LAB GENE TRANSFER,BETHESDA,MD 20892

Eckhaus, M
论文数: 0 引用数: 0
h-index: 0
机构: NATL INST HLTH,NATL CTR HUMAN GENOME RES,LAB GENE TRANSFER,BETHESDA,MD 20892

Collins, F
论文数: 0 引用数: 0
h-index: 0
机构: NATL INST HLTH,NATL CTR HUMAN GENOME RES,LAB GENE TRANSFER,BETHESDA,MD 20892

Shiloh, Y
论文数: 0 引用数: 0
h-index: 0
机构: NATL INST HLTH,NATL CTR HUMAN GENOME RES,LAB GENE TRANSFER,BETHESDA,MD 20892

Crawley, JN
论文数: 0 引用数: 0
h-index: 0
机构: NATL INST HLTH,NATL CTR HUMAN GENOME RES,LAB GENE TRANSFER,BETHESDA,MD 20892

Ried, T
论文数: 0 引用数: 0
h-index: 0
机构: NATL INST HLTH,NATL CTR HUMAN GENOME RES,LAB GENE TRANSFER,BETHESDA,MD 20892

Tagle, D
论文数: 0 引用数: 0
h-index: 0
机构: NATL INST HLTH,NATL CTR HUMAN GENOME RES,LAB GENE TRANSFER,BETHESDA,MD 20892

WynshawBoris, A
论文数: 0 引用数: 0
h-index: 0
机构: NATL INST HLTH,NATL CTR HUMAN GENOME RES,LAB GENE TRANSFER,BETHESDA,MD 20892
[5]
Telomere position effect in human cells
[J].
Baur, JA
;
Zou, Y
;
Shay, JW
;
Wright, WE
.
SCIENCE,
2001, 292 (5524)
:2075-2077

Baur, JA
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Texas, SW Med Ctr, Dept Cell Biol, Dallas, TX 75390 USA Univ Texas, SW Med Ctr, Dept Cell Biol, Dallas, TX 75390 USA

Zou, Y
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Texas, SW Med Ctr, Dept Cell Biol, Dallas, TX 75390 USA Univ Texas, SW Med Ctr, Dept Cell Biol, Dallas, TX 75390 USA

Shay, JW
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Texas, SW Med Ctr, Dept Cell Biol, Dallas, TX 75390 USA Univ Texas, SW Med Ctr, Dept Cell Biol, Dallas, TX 75390 USA

Wright, WE
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Texas, SW Med Ctr, Dept Cell Biol, Dallas, TX 75390 USA Univ Texas, SW Med Ctr, Dept Cell Biol, Dallas, TX 75390 USA
[6]
Telomeric recombination in mismatch repair deficient human colon cancer cells after telomerase inhibition
[J].
Bechter, OE
;
Zou, Y
;
Walker, W
;
Wright, WE
;
Shay, JW
.
CANCER RESEARCH,
2004, 64 (10)
:3444-3451

Bechter, OE
论文数: 0 引用数: 0
h-index: 0
机构: Univ Texas, SW Med Ctr, Dept Cell Biol, Dallas, TX 75390 USA

Zou, Y
论文数: 0 引用数: 0
h-index: 0
机构: Univ Texas, SW Med Ctr, Dept Cell Biol, Dallas, TX 75390 USA

Walker, W
论文数: 0 引用数: 0
h-index: 0
机构: Univ Texas, SW Med Ctr, Dept Cell Biol, Dallas, TX 75390 USA

Wright, WE
论文数: 0 引用数: 0
h-index: 0
机构: Univ Texas, SW Med Ctr, Dept Cell Biol, Dallas, TX 75390 USA

Shay, JW
论文数: 0 引用数: 0
h-index: 0
机构: Univ Texas, SW Med Ctr, Dept Cell Biol, Dallas, TX 75390 USA
[7]
Switching and signaling at the telomere
[J].
Blackburn, EH
.
CELL,
2001, 106 (06)
:661-673

Blackburn, EH
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Calif San Francisco, Dept Biochem & Biophys, San Francisco, CA 94143 USA Univ Calif San Francisco, Dept Biochem & Biophys, San Francisco, CA 94143 USA
[8]
Mice with bad ends: mouse models for the study of telomeres and telomerase in cancer and aging
[J].
Blasco, MA
.
EMBO JOURNAL,
2005, 24 (06)
:1095-1103

Blasco, MA
论文数: 0 引用数: 0
h-index: 0
机构:
Spanish Natl Canc Ctr CNIO, Mol Oncol Program, Telomeres & Telomerase Grp, Madrid 28029, Spain Spanish Natl Canc Ctr CNIO, Mol Oncol Program, Telomeres & Telomerase Grp, Madrid 28029, Spain
[9]
Telomerase beyond telomeres
[J].
Blasco, MA
.
NATURE REVIEWS CANCER,
2002, 2 (08)
:627-632

Blasco, MA
论文数: 0 引用数: 0
h-index: 0
机构:
Natl Biotechnol Ctr, Dept Immunol & Oncol, E-28049 Madrid, Spain Natl Biotechnol Ctr, Dept Immunol & Oncol, E-28049 Madrid, Spain
[10]
FUNCTIONAL-CHARACTERIZATION AND DEVELOPMENTAL REGULATION OF MOUSE TELOMERASE RNA
[J].
BLASCO, MA
;
FUNK, W
;
VILLEPONTEAU, B
;
GREIDER, CW
.
SCIENCE,
1995, 269 (5228)
:1267-1270

BLASCO, MA
论文数: 0 引用数: 0
h-index: 0
机构: COLD SPRING HARBOR LAB, COLD SPRING HARBOR, NY 11724 USA

FUNK, W
论文数: 0 引用数: 0
h-index: 0
机构: COLD SPRING HARBOR LAB, COLD SPRING HARBOR, NY 11724 USA

VILLEPONTEAU, B
论文数: 0 引用数: 0
h-index: 0
机构: COLD SPRING HARBOR LAB, COLD SPRING HARBOR, NY 11724 USA

GREIDER, CW
论文数: 0 引用数: 0
h-index: 0
机构: COLD SPRING HARBOR LAB, COLD SPRING HARBOR, NY 11724 USA