Telomeres and human disease: Ageing, cancer and beyond

被引:1248
作者
Blasco, MA [1 ]
机构
[1] Spanish Natl Canc Ctr CNIO, Telomeres & Telomerase Grp, Mol Oncol Program, Madrid 28029, Spain
关键词
D O I
10.1038/nrg1656
中图分类号
Q3 [遗传学];
学科分类号
071007 ; 090102 ;
摘要
Telomere length and telomerase activity are important factors in the pathobiology of human disease. Age-related diseases and premature ageing syndromes are characterized by short telomeres, which can compromise cell viability, whereas tumour cells can prevent telomere loss by aberrantly upregulating telomerase. Altered functioning of both telomerase and telomere-interacting proteins is present in some human premature ageing syndromes and in cancer, and recent findings indicate that alterations that affect telomeres at the level of chromatin structure might also have a role in human disease. These findings have inspired a number of potential therapeutic strategies that are based on telomerase and telomeres.
引用
收藏
页码:611 / 622
页数:12
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