Apoptotic activities of C2-ceramide and C2-dihydroceramide homologues against HL-60 cells

被引：33

作者：

Shikata, K ^{[1
]}

Niiro, H ^{[1
]}

Azuma, H ^{[1
]}

Ogino, K ^{[1
]}

Tachibana, T ^{[1
]}

机构：

[1] Osaka City Univ, Grad Sch Engn, Dept Appl & Bioappl Chem, Sumiyoshi Ku, Osaka 5588585, Japan

来源：

BIOORGANIC & MEDICINAL CHEMISTRY | 2003年 / 11卷 / 13期

关键词：

D O I：

10.1016/S0968-0896(03)00228-1

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The apoptotic activities of non-natural ceramide homologues, C2-homo-ceramide, C2-homo-dihydroceramide, C2-bishomo-ceramide and C2-bishomo-dihydroceramide, were examined using human leukemia HL-60 cells. The apoptotic activity was in order of C2-ceramide > C2-homo-ceramideapproximate toC2-bishomo-ceramide and the activities of the L-erythro- and D-erythro-ceramide homologues were similar. The morphological features of the cells, DNA fragmentations, proteolytic processing of pro-caspase-3 and the cleavage of PARP as the result of treatments with these homologues indicated that cell death was induced by apoptosis. (C) 2003 Elsevier Science Ltd. All rights reserved.

引用

页码：2723 / 2728

页数：6

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