The synthesis and biological characterization of a ceramide library

被引：61

作者：

Chang, YT

Choi, J

Ding, S

Prieschl, EE

Baumruker, T

Lee, JM

Chung, SK

Schultz, PG

机构：

[1] Scripps Res Inst, Dept Chem, La Jolla, CA 92037 USA

[2] Novartis Res Inst, Dept Immunol, Vienna, Austria

[3] Pohang Univ Sci & Technol, Dept Chem, Div Mol & Life Sci, Pohang 790784, South Korea

来源：

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 2002年 / 124卷 / 09期

关键词：

D O I：

10.1021/ja017576o

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A facile synthesis of a combinatorial ceramide library and their activities in the NF-κB pathway and in apoptosis induction/prevention were demonstrated. A novel NF-κB activating molecule was discovered among ceramide containing β-galactose, and the structural requirements of ceramides for apoptosis induction was elucidated. Copyright © 2002 American Chemical Society.

引用

页码：1856 / 1857

页数：2

共 14 条

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