Human brain imaging post-mortem - whole hemisphere technologies

被引：18

作者：

Hall, H ^{[1
]}

Hurd, Y ^{[1
]}

Pauli, S ^{[1
]}

Halldin, C ^{[1
]}

Sedvall, G ^{[1
]}

机构：

[1] Karolinska Inst, Karolinska Hosp, Dept Clin Neurosci, Psychiat Sect, S-17176 Stockholm, Sweden

来源：

INTERNATIONAL REVIEW OF PSYCHIATRY | 2001年 / 13卷 / 01期

关键词：

D O I：

10.1080/09540260020024141

中图分类号：

R749 [精神病学];

学科分类号：

100205 ;

摘要：

The use of whole post-mortem human brain hemispheres for the studies of the biochemical neuroanatomy is described. Cryosections prepared from whole hemispheres have been successfully used for in vitro radioligand autoradiography, in situ hybridization histochemistry and histochemistry. Functional autoradiography using 5-HT1A receptor stimulated [S-35] GTP gammaS binding and volume rendering of images from radioligand autoradiography to describe the distribution of D-2/D-3 dopamine receptors in three dimensions are also discussed. A detailed characterization of the biochemical neuroanatomy of several neuronal components can thus be obtained simultaneously in all regions in the normal and diseased brain, resulting in an extensive information on the human brain morphology and biochemistry.

引用

页码：12 / 17

页数：6

共 49 条

[21] NCQ 298, A NEW SELECTIVE IODINATED SALICYLAMIDE LIGAND FOR THE LABELING OF DOPAMINE-D2 RECEPTORS
HALL, H
HOGBERG, T
HALLDIN, C
KOHLER, C
STROM, P
ROSS, SB
LARSSON, SA
FARDE, L
[J]. PSYCHOPHARMACOLOGY, 1991, 103 (01) : 6 - 18
[22] Autoradiographic comparison of [I-125]epidepride and [I-125]NCQ 298 binding to human brain extrastriated dopamine receptors
Hall, H
Halldin, C
Jerning, E
Osterlund, M
Farde, L
Sedvall, G
[J]. NUCLEAR MEDICINE AND BIOLOGY, 1997, 24 (05): : 389 - 393
[23] Autoradiographic localization of 5-HT1A receptors in the post-mortem human brain using [H-3]WAY-100635 and [C-11]WAY-100635
Hall, H
Lundkvist, C
Halldin, C
Farde, L
Pike, VW
McCarron, JA
Fletcher, A
Cliffe, IA
Barf, T
Wikstrom, H
Sedvall, G
[J]. BRAIN RESEARCH, 1997, 745 (1-2) : 96 - 108
[24] Hall H, 2000, SYNAPSE, V38, P421, DOI 10.1002/1098-2396(20001215)38:4<421::AID-SYN7>3.0.CO
[25] 2-X
[26] HALL H, UNPUB AUTORADIOGRAPH
[27] HALLDIN C, 1996, TXB DRUG DESIGN DEV, P178
[28] SEROTONIN RECEPTORS IN THE HUMAN-BRAIN .1. CHARACTERIZATION AND AUTORADIOGRAPHIC LOCALIZATION OF 5-HT1A RECOGNITION SITES - APPARENT ABSENCE OF 5-HT1B RECOGNITION SITES
HOYER, D
PAZOS, A
PROBST, A
PALACIOS, JM
[J]. BRAIN RESEARCH, 1986, 376 (01) : 85 - 96
[29] Hurd YL, 1999, J COMP NEUROL, V411, P56, DOI 10.1002/(SICI)1096-9861(19990816)411:1<56::AID-CNE5>3.0.CO
[30] 2-3

← 1 2 3 4 5 →