FHIT gene therapy prevents tumor development in Fhit-deficient mice

被引：138

作者：

Dumon, KR ^{[1
]}

Ishii, H ^{[1
]}

Fong, LYY ^{[1
]}

Zanesi, N ^{[1
]}

Fidanza, V ^{[1
]}

Mancini, R ^{[1
]}

Vecchione, A ^{[1
]}

Baffa, R ^{[1
]}

Trapasso, F ^{[1
]}

During, MJ ^{[1
]}

Huebner, K ^{[1
]}

Croce, CM ^{[1
]}

机构：

[1] Thomas Jefferson Univ, Jefferson Med Coll, Kimmel Canc Ctr, Philadelphia, PA 19107 USA

来源：

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA | 2001年 / 98卷 / 06期

关键词：

D O I：

10.1073/pnas.061020098

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

The tumor suppressor gene FHIT spans a common fragile site and is highly susceptible to environmental carcinogens. FHIT inactivation and loss of expression is found in a large fraction of premaligant and malignant lesions. In this study, we were able to inhibit tumor development by oral gene transfer, using adenoviral or adenoassociated viral vectors expressing the human FHIT gene, in heterozygous Fhit(+/-) knockout mice, that are prone to tumor development after carcinogen exposure. We therefore suggest that FHIT gene therapy could be a novel clinical approach not only in treatment of early stages of cancer, but also in prevention of human cancer.

引用

页码：3346 / 3351

页数：6

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