MicroRNA signature predicts survival and relapse in lung cancer

被引：728

作者：

Yu, Sung-Liang ^{[1
,2
,5
]}

Chen, Hsuan-Yu ^{[1
,6
]}

Chang, Gee-Chen ^{[9
,11
]}

Chen, Chih-Yi ^{[7
,10
,12
]}

Chen, Huei-Wen ^{[13
]}

Singh, Sher ^{[14
]}

Cheng, Chiou-Ling ^{[1
]}

Yu, Chong-Jen ^{[4
]}

Lee, Yung-Chie ^{[3
]}

Chen, Han-Shiang ^{[15
,16
]}

Su, Te-Jen ^{[1
,11
]}

Chiang, Ching-Cheng ^{[1
]}

Li, Han-Ni ^{[1
]}

Hong, Qi-Sheng ^{[1
]}

Su, Hsin-Yuan ^{[1
]}

Chen, Chun-Chieh ^{[1
]}

Chen, Wan-Jiun ^{[13
]}

Liu, Chun-Chi ^{[11
]}

Chan, Wing-Kai ^{[5
]}

Chen, Wei J. ^{[1
,6
]}

Li, Ker-Chau ^{[7
,17
]}

Chen, Jeremy J. W. ^{[1
,11
]}

Yang, Pan-Chyr ^{[1
,4
,8
]}

机构：

[1] Natl Taiwan Univ, Coll Med, NTU Ctr Genem Med, Taipei 100, Taiwan

[2] Natl Taiwan Univ, Coll Med, Dept Clin Lab Sci & Med Biotechnol, Taipei 100, Taiwan

[3] Natl Taiwan Univ Hosp, Dept Surg, Taipei 100, Taiwan

[4] Natl Taiwan Univ Hosp, Dept Internal Med, Taipei 100, Taiwan

[5] Natl Taiwan Univ Hosp, Dept Med Res, Taipei 100, Taiwan

[6] Natl Taiwan Univ, Coll Med, Grad Inst Epidemiol, Taipei 100, Taiwan

[7] Acad Sinica, Inst Stat Sci, Taipei 115, Taiwan

[8] Acad Sinica, Inst Biomed Sci, Taipei 115, Taiwan

[9] Taichung Vet Gen Hosp, Div Chest Med, Dept Internal Med, Taichung 407, Taiwan

[10] Taichung Vet Gen Hosp, Div Thorac Surg, Dept Surg, Taichung 407, Taiwan

[11] Natl Chung Hsing Univ, Inst Biomed Sci & Mol Biol, Taichung 402, Taiwan

[12] China Med Univ Hosp, Sch Med, Dept Surg, Div Thorac Surg, Taichung 404, Taiwan

[13] Natl Yang Ming Univ, Coll Med, Inst Pharmacol, Taipei 112, Taiwan

[14] Natl Taiwan Normal Univ, Dept Life Sci, Taipei 116, Taiwan

[15] Hualien Tzu Chi Med Ctr, Dept Colon & Rectal Surg, Hualien 970, Taiwan

[16] Hualien Tzu Chi Med Ctr, Dept Surg, Hualien 970, Taiwan

[17] Univ Calif Los Angeles, Dept Stat, Los Angeles, CA 90095 USA

来源：

CANCER CELL | 2008年 / 13卷 / 01期

基金：

美国国家科学基金会;

关键词：

D O I：

10.1016/j.ccr.2007.12.008

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

We investigated whether microRNA expression profiles can predict clinical outcome of NSCLC patients. Using real-time RT-PCR, we obtained microRNA expressions in 112 NSCLC patients, which were divided into the training and testing sets. Using Cox regression and risk-score analysis, we identified a five-microRNA signature for the prediction of treatment outcome of NSCLC in the training set. This microRNA signature was validated by the testing set and an independent cohort. Patients with high-risk scores in their microRNA signatures had poor overall and disease-free survivals compared to the low-risk-score patients. This microRNA signature is an independent predictor of the cancer relapse and survival of NSCLC patients.

引用

页码：48 / 57

页数：10

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