MicroRNA-cancer connection: The beginning of a new tale

被引：908

作者：

Calin, George Adrian

Croce, Carlo Maria

机构：

[1] Ohio State Univ, Ctr Comprehens Canc, Columbus, OH 43210 USA

[2] Ohio State Univ, Dept Mol Virol Immunol & Med Genet, Columbus, OH 43210 USA

来源：

CANCER RESEARCH | 2006年 / 66卷 / 15期

关键词：

D O I：

10.1158/0008-5472.CAN-06-0800

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Cancer initiation and progression can involve microRNAs (miRNA), which are small noncoding RNAs that can regulate gene expression. Their expression profiles can be used for the classification, diagnosis, and prognosis of human malignancies. Loss or amplification of miRNA genes has been reported in a variety of cancers, and altered patterns of miRNA expression may affect cell cycle and survival programs. Germ-line and somatic mutations in miRNAs or polymorphisms in the mRNAs targeted by miRNAs may also contribute to cancer predisposition and progression. We propose that alterations in miRNA genes play a critical role in the pathophysiology of many, perhaps all, human cancers.

引用

页码：7390 / 7394

页数：5

共 40 条

[1] MicroRNA pathways in flies and worms: Growth, death, fat, stress, and timing [J].

Ambros, V .

CELL, 2003, 113 (06) :673-676

[2] miR-15a and miR-16-1 down-regulation in pituitary adenomas [J].

Bottoni, A ;

Piccin, D ;

Tagliati, F ;

Luchin, A ;

Zatelli, MC ;

Uberti, ECD .

JOURNAL OF CELLULAR PHYSIOLOGY, 2005, 204 (01) :280-285

[3] Familial cancer associated with a polymorphism in ARLTS1 [J].

Calin, GA ;

Trapasso, F ;

Shimizu, M ;

Dumitru, CD ;

Yendamuri, S ;

Godwin, AK ;

Ferracin, M ;

Bernardi, G ;

Chatterjee, D ;

Baldassarre, G ;

Rattan, S ;

Alder, H ;

Mabuchi, H ;

Shiraishi, T ;

Hansen, LL ;

Overgaard, J ;

Herlea, V ;

Mauro, FR ;

Dighiero, G ;

Movsas, B ;

Rassenti, L ;

Kipps, T ;

Baffa, R ;

Fusco, A ;

Mori, M ;

Russo, G ;

Liu, CG ;

Neuberg, D ;

Bullrich, F ;

Negrini, M ;

Croce, CM .

NEW ENGLAND JOURNAL OF MEDICINE, 2005, 352 (16) :1667-1676

[4] Frequent deletions and down-regulation of micro-RNA genes miR15 and miR16 at 13q14 in chronic lymphocytic leukemia [J].

Calin, GA ;

Dumitru, CD ;

Shimizu, M ;

Bichi, R ;

Zupo, S ;

Noch, E ;

Aldler, H ;

Rattan, S ;

Keating, M ;

Rai, K ;

Rassenti, L ;

Kipps, T ;

Negrini, M ;

Bullrich, F ;

Croce, CM .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2002, 99 (24) :15524-15529

[5] Human microRNA genes are frequently located at fragile sites and genomic regions involved in cancers [J].

Calin, GA ;

Sevignani, C ;

Dan Dumitru, C ;

Hyslop, T ;

Noch, E ;

Yendamuri, S ;

Shimizu, M ;

Rattan, S ;

Bullrich, F ;

Negrini, M ;

Croce, CM .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2004, 101 (09) :2999-3004

[6] MicroRNA profiling reveals distinct signatures in B cell chronic lymphocytic leukemias [J].

Calin, GA ;

Liu, CG ;

Sevignani, C ;

Ferracin, M ;

Felli, N ;

Dumitru, CD ;

Shimizu, M ;

Cimmino, A ;

Zupo, S ;

Dono, M ;

Dell'Aquila, ML ;

Alder, H ;

Rassenti, L ;

Kipps, TJ ;

Bullrich, F ;

Negrini, M ;

Croce, CM .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2004, 101 (32) :11755-11760

[7] Definition and diagnosis of sporadic and familial chronic lymphocytic leukemia [J].

Catovsky, D .

HEMATOLOGY-ONCOLOGY CLINICS OF NORTH AMERICA, 2004, 18 (04) :783-+

[8] MicroRNA-21 is an antiapoptotic factor in human glioblastoma cells [J].

Chan, JA ;

Krichevsky, AM ;

Kosik, KS .

CANCER RESEARCH, 2005, 65 (14) :6029-6033

[9] Extensive modulation of a set of microRNAs in primary glioblastoma [J].

Ciafrè, SA ;

Galardi, S ;

Mangiola, A ;

Ferracin, M ;

Liu, CG ;

Sabatino, G ;

Negrini, M ;

Maira, G ;

Croce, CM ;

Farace, MG .

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2005, 334 (04) :1351-1358

[10] miR-15 and miR-16 induce apoptosis by targeting BCL2 [J].

Cimmino, A ;

Calin, GA ;

Fabbri, M ;

Iorio, MV ;

Ferracin, M ;

Shimizu, M ;

Wojcik, SE ;

Aqeilan, RI ;

Zupo, S ;

Dono, M ;

Rassenti, L ;

Alder, H ;

Volinia, S ;

Liu, CG ;

Kipps, TJ ;

Negrini, M ;

Croce, CM .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2005, 102 (39) :13944-13949

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