MicroRNA-cancer connection: The beginning of a new tale

被引：908

作者：

Calin, George Adrian

Croce, Carlo Maria

机构：

[1] Ohio State Univ, Ctr Comprehens Canc, Columbus, OH 43210 USA

[2] Ohio State Univ, Dept Mol Virol Immunol & Med Genet, Columbus, OH 43210 USA

来源：

CANCER RESEARCH | 2006年 / 66卷 / 15期

关键词：

D O I：

10.1158/0008-5472.CAN-06-0800

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Cancer initiation and progression can involve microRNAs (miRNA), which are small noncoding RNAs that can regulate gene expression. Their expression profiles can be used for the classification, diagnosis, and prognosis of human malignancies. Loss or amplification of miRNA genes has been reported in a variety of cancers, and altered patterns of miRNA expression may affect cell cycle and survival programs. Germ-line and somatic mutations in miRNAs or polymorphisms in the mRNAs targeted by miRNAs may also contribute to cancer predisposition and progression. We propose that alterations in miRNA genes play a critical role in the pathophysiology of many, perhaps all, human cancers.

引用

收藏

页码：7390 / 7394

页数：5

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