Reduced expression of the let-7 microRNAs in human lung cancers in association with shortened postoperative survival

被引：1940

作者：

Takamizawa, J

Konishi, H

Yanagisawa, K

Tomida, S

Osada, H

Endoh, H

Harano, T

Yatabe, Y

Nagino, M

Nimura, Y

Mitsudomi, T

Takahashi, T

机构：

[1] Aichi Canc Ctr, Res Inst, Div Mol Oncol, Chikusa Ku, Nagoya, Aichi 4648681, Japan

[2] Aichi Canc Ctr Hosp, Dept Anat & Mol Diagnost Pathol, Nagoya, Aichi 464, Japan

[3] Aichi Canc Ctr Hosp, Dept Thorac Surg, Nagoya, Aichi 464, Japan

[4] Nagoya Univ, Grad Sch Med, Dept Surg, Div Surg Oncol, Nagoya, Aichi, Japan

来源：

CANCER RESEARCH | 2004年 / 64卷 / 11期

关键词：

D O I：

10.1158/0008-5472.CAN-04-0637

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

In this study, we report for the first time reduced expression of the let-7 microRNA in human lung cancers. Interestingly, 143 lung cancer cases that had undergone potentially curative resection could be classified into two major groups according to let-7 expression in unsupervised hierarchical analysis, showing significantly shorter survival after potentially curative resection in cases with reduced let-7 expression (P = 0.0003). Multivariate COX regression analysis showed this prognostic impact to be independent of disease stage (hazard ratio = 2.17; P = 0.009). In addition, overexpression of let-7 in A549 lung adenocarcinoma cell line inhibited lung cancer cell growth in vitro. This study represents the first report of reduced expression of let-7 and the potential clinical and biological effects of such a microRNA alteration.

引用

收藏

页码：3753 / 3756

页数：4

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