Stroke was predicted by dimensions of quality of life in treated hypertensive men

被引:24
作者
Agewall, S [1 ]
Wikstrand, J
Fagerberg, B
机构
[1] Univ Gothenburg, Sahlgrens Univ Hosp, Dept Med, S-41345 Gothenburg, Sweden
[2] Univ Gothenburg, Sahlgrens Univ Hosp, Wallenberg Lab Cardiovasc Res, S-41345 Gothenburg, Sweden
关键词
psychiatric status rating scales; quality of life; risk factors; social support; stroke;
D O I
10.1161/01.STR.29.11.2329
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
Background and Purpose-Psychosocial factors have been suggested as risk factors for atherosclerotic disease. The purpose of the present study was to examine whether quality of life predicted strokes and acute coronary events in a prospective study. Methods-The study included 412 treated hypertensive men, aged 50 to 72 years, with II of the following: serum cholesterol greater than or equal to 6.5 mmol/L, smoking, or diabetes mellitus. The Minor Symptoms Evaluation Profile (MSEP) was used to estimate quality of life at entry. Incidences of stroke and acute coronary events were recorded during follow-up. The median follow-up time was 6.6 years. Results-Sixty-four patients had an acute coronary event, and 37 had a stroke during the follow-up period. The Cox regression analyses revealed that the 3 dimensions of MSEP at entry were significant predictors of stroke. The relationship between low contentment at entry and the incidence of stroke during follow-up remained significant (relative risk = 1.04; 95% CI, 1.01 to 1.06; P=0.003) even after adjustment for other potential cardiovascular risk factors. Vitality also remained an independent predictor for stroke after adjustment for these potential cardiovascular risk factors (relative risk=1.04; 95% CI, 1.02 to 1.06; P<0.0001). There was no relationship between MSEP score at entry and myocardial infarction during follow-up. Conclusions-An independent and significant association between reduced well-being at entry and future stroke was observed in hypertensive men at high cardiovascular risk. The causal relationship is not known, however.
引用
收藏
页码:2329 / 2333
页数:5
相关论文
共 30 条
[1]   EFFECTS OF CAPTOPRIL ON ATHEROSCLEROSIS IN CYNOMOLGUS MONKEYS [J].
ABERG, G ;
FERRER, P .
JOURNAL OF CARDIOVASCULAR PHARMACOLOGY, 1990, 15 :S65-S72
[2]   THE EFFICACY OF MULTIPLE RISK FACTOR INTERVENTION IN TREATED HYPERTENSIVE MEN DURING LONG-TERM FOLLOW-UP [J].
AGEWALL, S ;
WIKSTRAND, J ;
SAMUELSSON, O ;
PERSSON, B ;
ANDERSSON, OK ;
FAGERBERG, B .
JOURNAL OF INTERNAL MEDICINE, 1994, 236 (06) :651-659
[3]   Negative feelings (discontent) predict progress of intima-media thickness of the common carotid artery in treated hypertensive men at high cardiovascular risk [J].
Agewall, S ;
Wikstrand, J ;
Dahlof, C ;
Fagerberg, B .
AMERICAN JOURNAL OF HYPERTENSION, 1996, 9 (06) :545-550
[4]  
[Anonymous], WHO TECHN REP SER
[5]   SOCIAL NETWORKS, HOST-RESISTANCE, AND MORTALITY - 9-YEAR FOLLOW-UP-STUDY OF ALAMEDA COUNTY RESIDENTS [J].
BERKMAN, LF ;
SYME, SL .
AMERICAN JOURNAL OF EPIDEMIOLOGY, 1979, 109 (02) :186-204
[6]   TYPE-A BEHAVIOR AND SURVIVAL AFTER ACUTE MYOCARDIAL-INFARCTION [J].
CASE, RB ;
HELLER, SS ;
CASE, NB ;
MOSS, AJ .
NEW ENGLAND JOURNAL OF MEDICINE, 1985, 312 (12) :737-741
[7]   DEPRESSIVE SYMPTOMS AND OTHER PSYCHOSOCIAL FACTORS AS PREDICTORS OF STROKE IN THE ELDERLY [J].
COLANTONIO, A ;
KASL, SV ;
OSTFELD, AM .
AMERICAN JOURNAL OF EPIDEMIOLOGY, 1992, 136 (07) :884-894
[8]   DOCUMENTATION OF AN INSTRUMENT FOR ASSESSMENT OF SUBJECTIVE CNS-RELATED SYMPTOMS DURING CARDIOVASCULAR PHARMACOTHERAPY [J].
DAHLOF, C ;
DIMENAS, E ;
OLOFSSON, B .
CARDIOVASCULAR DRUGS AND THERAPY, 1989, 3 (06) :919-927
[9]  
Dahlof C, 1990, Scand J Prim Health Care Suppl, V1, P19
[10]   DIFFERENCES IN THE SUBJECTIVE WELL-BEING AND SYMPTOMS OF NORMOTENSIVES, BORDERLINE HYPERTENSIVES AND HYPERTENSIVES [J].
DIMENAS, ES ;
WIKLUND, IK ;
DAHLOF, CG ;
LINDVALL, KG ;
OLOFSSON, BK ;
DEFAIRE, UH .
JOURNAL OF HYPERTENSION, 1989, 7 (11) :885-890