Ferrocenoyl pyridine arene ruthenium complexes with anticancer properties:: Synthesis, structure, electrochemistry, and cytotoxicity

被引：129

作者：

Auzias, Mathieu ^{[1
]}

Therrien, Bruno ^{[1
]}

Suess-Fink, Georg ^{[1
]}

Stepnicka, Petr ^{[2
]}

Ang, Wee Han ^{[3
]}

Dyson, Paul J. ^{[3
]}

机构：

[1] Univ Neuchatel, Inst Chim, CH-2009 Neuchatel, Switzerland

[2] Charles Univ Prague, Fac Sci, Dept Inorgan Chem, CZ-12840 Prague 2, Czech Republic

[3] Ecole Polytech Fed Lausanne, Inst Sci & Ingn Chim, CH-1015 Lausanne, Switzerland

来源：

INORGANIC CHEMISTRY | 2008年 / 47卷 / 02期

关键词：

D O I：

10.1021/ic7018742

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

Organometallic ruthenium(II) complexes of general formula [RU(eta(6)-arene)Cl-2(NC5H4OOC-C5H4FeC5H5)], where arene = C6H6 (1), C6H5Me (2), p-(PrC6H4Me)-Pr-i (3), and C6Me6 (4), and of general formula [Ru(eta(6)-arene)Cl-2](2)(NC5H4OOC-C5H4FeC5H4-COOC5H4N), where arene = p-(PrC6H4Me)-Pr-i (5) and C6Me6 (6), have been synthesized and characterized, the molecular structures of these complexes being confirmed by single-crystal X-ray structure analysis of complex 4 as a representative example. The redox properties and in vitro anticancer activities of complexes 1-6 have been studied. All the compounds are moderately cytotoxic toward the A2780 and A2780cisR (cisplatin-resistant) human ovarian carcinoma cell lines. The diruthenium arene complexes 5 and 6 are about twice as active as their mononuclear analogues 3 and 4. Cyclic voltammetry revealed a good correlation of the Ru-II/Ru-III redox potentials of 1-4 and the number of alkyl substituents in the arene ligand.

引用

页码：578 / 583

页数：6

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