The role of heat shock proteins Hsp70 and Hsp27 in cellular protection of the central nervous system

被引:199
作者
Franklin, TB
Krueger-Naug, AM
Clarke, DB
Arrigo, AP
Currie, RW [1 ]
机构
[1] Dalhousie Univ, Dept Anat & Neurobiol, Mol Neurobiol Lab, Halifax, NS B3H 1X5, Canada
[2] Dalhousie Univ, Dept Anat & Neurobiol, Cell Restorat Lab, Halifax, NS B3H 1X5, Canada
[3] Univ Lyon 1, Ctr Genet Mol & Cellulaire, Lab Stress Oxidant Chaperons & Apoptose, F-69622 Villeurbanne, France
关键词
Hsp27; Hsp70; neuroprotection; hyperthermia; ischemia; apoptosis; brain;
D O I
10.1080/02656730500069955
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
Heat shock proteins ( Hsps) are highly conserved and under physiological conditions act as molecular chaperones and/ or have anti- apoptotic activities. Expression in the brain of two heat shock proteins, the 70 kDa Hsp ( Hsp70) and the 27 kDa Hsp ( Hsp27), is notable because both proteins are highly inducible in glial cells and neurons following a wide range of noxious stimuli including ischemia, epileptic seizure and hyperthermia. In the central nervous system, constitutive expression of Hsp27 is limited to many ( but not all) sensory and motor neurons of the brain stem and spinal cord, while there is little or no constitutive expression of Hsp70. However, inducible expression of both Hsp70 and Hsp27 is present in many areas of the brain and retina and is associated with cellular resistance to a variety of insults. The potential for manipulating the expression levels of Hsps for therapeutic advantage in neurodegenerative diseases such as Alzheimer's disease, stroke and glaucoma will be explored.
引用
收藏
页码:379 / 392
页数:14
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