Functional atlas of the integrin adhesome

被引：853

作者：

Zaidel-Bar, Ronen ^{[1
]}

Itzkovitz, Shalev

Ma'ayan, Avi

Iyengar, Ravi

Geiger, Benjamin

机构：

[1] Weizmann Inst Sci, Dept Mol Cell Biol, IL-76100 Rehovot, Israel

[2] Mt Sinai Sch Med, Dept Pharmacol & Biol Chem, New York, NY 10029 USA

来源：

NATURE CELL BIOLOGY | 2007年 / 9卷 / 08期

关键词：

D O I：

10.1038/ncb0807-858

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

A detailed depiction of the 'integrin adhesome', consisting of a complex network of 156 components linked together and modified by 690 interactions is presented. Different views of the network reveal several functional 'subnets' that are involved in switching on or off many of the molecular interactions within the network, consequently affecting cell adhesion, migration and cytoskeletal organization. Examination of the adhesome network motifs reveals a relatively small number of key motifs, dominated by three-component complexes in which a scaffolding molecule recruits both a signalling molecule and its downstream target. We discuss the role of the different network modules in regulating the structural and signalling functions of cell-matrix adhesions.

引用

页码：858 / 868

页数：11

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