piRNAs, transposon silencing, and Drosophila germline development

被引:115
作者
Khurana, Jaspreet S.
Theurkauf, William [1 ]
机构
[1] Univ Massachusetts, Sch Med, Program Cell & Dev Dynam, Worcester, MA 01605 USA
关键词
PIWI-INTERACTING RNAS; OSKAR MESSENGER-RNA; EMBRYONIC AXIS SPECIFICATION; SELFISH GENETIC ELEMENTS; DOUBLE-STRAND BREAKS; STEM-CELLS; HISTONE H3; MELANOGASTER GERMLINE; LYSINE-9; METHYLATION; SYNAPTONEMAL COMPLEX;
D O I
10.1083/jcb.201006034
中图分类号
Q2 [细胞生物学];
学科分类号
071009 ; 090102 ;
摘要
Transposons are prominent features of most eukaryotic genomes and mobilization of these elements triggers genetic instability. Transposon silencing is particularly critical in the germline, which maintains the heritable genetic complement. Piwi-interacting RNAs (piRNAs) have emerged as central players in transposon silencing and genome maintenance during germline development. In particular, research on Drosophila oogenesis has provided critical insights into piRNA biogenesis and transposon silencing. In this system, the ability to place piRNA mutant phenotypes within a well-defined developmental framework has been instrumental in elucidating the molecular mechanisms underlying the connection between piRNAs and transposon control.
引用
收藏
页码:905 / 913
页数:9
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