FANCF methylation contributes to chemoselectivity in ovarian cancer

被引：63

作者：

Olopade, OI ^{[1
]}

Wei, MJ ^{[1
]}

机构：

[1] Univ Chicago, Med Ctr, Dept Med, Ctr Clin Canc Genet, Chicago, IL 60637 USA

来源：

CANCER CELL | 2003年 / 3卷 / 05期

关键词：

D O I：

10.1016/S1535-6108(03)00111-9

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

A new model of ovarian cancer tumor progression implicates aberrant FANCF promoter methylation that is associated with gene silencing and disruption of the Fanconi-anemia-BRCA pathway. Disruption of the pathway occurs de novo in ovarian cancers and may contribute to selective sensitivity to platinum salts.

引用

页码：417 / 420

页数：4

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