Angiotensin converting enzyme (ACE) inhibitory flavonoids from Erythroxylum laurifolium

被引：31

作者：

Hansen, K

Adsersen, A

Smitt, UW

Nyman, U

Christensen, SB

Schwartner, C

Wagner, H

机构：

[1] ROYAL DANISH SCH PHARM,DEPT MED CHEM,DK-2100 COPENHAGEN O,DENMARK

[2] UNIV MUNICH,INST PHARMACEUT BIOL,D-80333 MUNICH,GERMANY

来源：

PHYTOMEDICINE | 1996年 / 2卷 / 04期

关键词：

anti-hypertensive effect; angiotensin converting enzyme; ACE; quercitrin; afzelin; quercetin-3-O-rhamnoside; kaempferol-3-O-rhamnoside; synergism;

D O I：

10.1016/S0944-7113(96)80075-4

中图分类号：

Q94 [植物学];

学科分类号：

071001 [植物学];

摘要：

In our screening program for antihypertensive properties of plants in traditional use, the 99% ethanol extract of Erythroxylum laurifolium leaves showed interesting angiotensin converting enzyme (ACE) inhibitory activity. The activity was found to be due to proanthocyanidins or condensed tannins and the flavonoids quercetin-3-O-rhamnoside (quercitrin) (IC50 = 0.67 mM) and kaempferol-3-O-rhamnoside (afzelin) (IC50 = 2.8 mM). In addition, quercitrin with afzelin demonstrated in vitro synergistic ACE inhibitory activity.

引用

页码：313 / 317

页数：5

共 23 条

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