Mutations associated with Sulfadoxine-pyrimethamine and chlorproguanil resistance in Plasmodium falciparum isolates from Blantyre, Malawi

被引：52

作者：

Alker, AP ^{[1
]}

Mwapasa, V

Purfield, A

Rogerson, SJ

Molyneux, ME

Kamwendo, DD

Tadesse, E

Chaluluka, E

Meshnick, SR

机构：

[1] Univ N Carolina, Sch Publ Hlth, Dept Epidemiol, Chapel Hill, NC 27599 USA

[2] Coll Med, Dept Community Hlth, Blantyre, Malawi

[3] Univ N Carolina, Sch Med, Dept Microbiol, Chapel Hill, NC USA

[4] Univ Melbourne, Dept Med, Parkville, Vic 3052, Australia

[5] Malawi Liverpool Wellcome Trust Clin Res Programm, Coll Med, Blantyre, Malawi

[6] Univ Michigan, Dept Epidemiol, Ann Arbor, MI 48109 USA

[7] Coll Med Blantyre, Dept Obstet & Gynecol, Blantyre, Malawi

来源：

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 2005年 / 49卷 / 09期

关键词：

D O I：

10.1128/AAC.49.9.3919-3921.2005

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

We conducted a prevalence study of mutations in Plasmodium falciparum that are associated with antifolate resistance in Blantyre, Malawi. The dihydrofolate reductase 164-Leu mutation, which confers resistance to both pyrimethamine and chlorproguanil, was found in 4.7% of the samples. Previously unreported mutations in dihydropteroate synthase were also found.

引用

页码：3919 / 3921

页数：3

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