Highly pyrimethamine-resistant alleles of dihydrofolate reductase in isolates of Plasmodium falciparum from Tanzania

被引：42

作者：

Hastings, MD

Bates, SJ

Blackstone, EA

Monks, SM

Mutabingwa, TK

Sibley, CH

机构：

[1] Univ Washington, Dept Genet, Seattle, WA 98195 USA

[2] Univ Washington, Dept Biostat, Seattle, WA 98195 USA

[3] Natl Inst Med Res, Amani Tanga, Tanzania

来源：

TRANSACTIONS OF THE ROYAL SOCIETY OF TROPICAL MEDICINE AND HYGIENE | 2002年 / 96卷 / 06期

关键词：

malaria; Plasmodium falciparum; chemotherapy; drug resistance; antimalarial drugs; antifolate; Tanzania;

D O I：

10.1016/S0035-9203(02)90349-4

中图分类号：

R1 [预防医学、卫生学];

学科分类号：

1004 ; 120402 ;

摘要：

In 2000 we used a sensitive technique to examine 9 isolates from malaria patients in Muheza, Tanzania who had failed treatment with sulfadoxine-pyrimethamine (SP). Three isolates carried, at low levels, the leucine to isoleucine change at amino acid 164 that is associated with clinical failure of SP. Numerous other highly resistant alleles were also observed.

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页码：674 / 676

页数：3

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