Pyrimethamine-sulfadoxine resistance in Plasmodium falciparum:: what next?

被引：295

作者：

Sibley, CH

Hyde, JE

Sims, PFG

Plowe, CV

Kublin, JG

Mberu, EK

Cowman, AF

Winstanley, PA

Watkins, WM

Nzila, AM

机构：

[1] Univ Washington, Dept Genet, Seattle, WA 98195 USA

[2] Univ Manchester, Dept Biomol Sci, Manchester M60 1QD, Lancs, England

[3] Univ Maryland, Sch Med, Malaria Sect, Ctr Vaccine Dev, Baltimore, MD 21201 USA

[4] Univ Malawi, Malaria Project, Coll Med, Blantyre, Malawi

[5] Kenya Govt Med Res Ctr, Wellcome Trust Collaborat Res Programme, Ctr Geog Med Res Coast, Kilifi, Kenya

[6] Walter & Eliza Hall Inst Med Res, Melbourne, Vic 3050, Australia

[7] Univ Liverpool, Dept Pharmacol & Therapeut, Liverpool L69 3BX, Merseyside, England

来源：

TRENDS IN PARASITOLOGY | 2001年 / 17卷 / 12期

关键词：

D O I：

10.1016/S1471-4922(01)02085-2

中图分类号：

R38 [医学寄生虫学]; Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ; 100103 ;

摘要：

Chemotherapy remains the only practicable tool to control falciparum malaria in sub-Saharan Africa, where > 90% of the world's burden of malaria mortality and morbidity occurs. Resistance is rapidly eroding the efficacy of chloroquine, and the combination pyrimethamine-sulfadoxine is the most commonly chosen alternative. Resistant populations of Plasmodium falciparum were selected extremely rapidly in Southeast Asia and South America. If this happens in sub-Saharan Africa, it will be a public health disaster because no inexpensive alternative is currently available. This article reviews the molecular mechanisms of this resistance and discusses how to extend the therapeutic life of antifolate drugs.

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收藏

页码：582 / 588

页数：7

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