Pyrimethamine-sulfadoxine resistance in Plasmodium falciparum:: what next?

被引：295

作者：

Sibley, CH

Hyde, JE

Sims, PFG

Plowe, CV

Kublin, JG

Mberu, EK

Cowman, AF

Winstanley, PA

Watkins, WM

Nzila, AM

机构：

[1] Univ Washington, Dept Genet, Seattle, WA 98195 USA

[2] Univ Manchester, Dept Biomol Sci, Manchester M60 1QD, Lancs, England

[3] Univ Maryland, Sch Med, Malaria Sect, Ctr Vaccine Dev, Baltimore, MD 21201 USA

[4] Univ Malawi, Malaria Project, Coll Med, Blantyre, Malawi

[5] Kenya Govt Med Res Ctr, Wellcome Trust Collaborat Res Programme, Ctr Geog Med Res Coast, Kilifi, Kenya

[6] Walter & Eliza Hall Inst Med Res, Melbourne, Vic 3050, Australia

[7] Univ Liverpool, Dept Pharmacol & Therapeut, Liverpool L69 3BX, Merseyside, England

来源：

TRENDS IN PARASITOLOGY | 2001年 / 17卷 / 12期

关键词：

D O I：

10.1016/S1471-4922(01)02085-2

中图分类号：

R38 [医学寄生虫学]; Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ; 100103 ;

摘要：

Chemotherapy remains the only practicable tool to control falciparum malaria in sub-Saharan Africa, where > 90% of the world's burden of malaria mortality and morbidity occurs. Resistance is rapidly eroding the efficacy of chloroquine, and the combination pyrimethamine-sulfadoxine is the most commonly chosen alternative. Resistant populations of Plasmodium falciparum were selected extremely rapidly in Southeast Asia and South America. If this happens in sub-Saharan Africa, it will be a public health disaster because no inexpensive alternative is currently available. This article reviews the molecular mechanisms of this resistance and discusses how to extend the therapeutic life of antifolate drugs.

引用

页码：582 / 588

页数：7

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