Stereoselective one-pot synthesis of beta-lactams by reaction of 2-pyridylthioesters with imines in the presence of AlBr3 or EtAlCl(2)

被引：11

作者：

Annunziata, R

Benaglia, M

Cinquini, M

Cozzi, F

Martini, O

Molteni, V

机构：

[1] UNIV MILAN,CTR CNR,I-20133 MILAN,ITALY

[2] UNIV MILAN,DIPARTIMENTO CHIM ORGAN & IND,I-20133 MILAN,ITALY

来源：

TETRAHEDRON | 1996年 / 52卷 / 07期

关键词：

D O I：

10.1016/0040-4020(95)01087-4

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The reactions of some 2-pyridylthioesters with imines in the presence of AlBr3 or EtAlCl(2) and of a tertiary amine afford beta-lactams in a simple one-pot procedure with fair to high trans stereoselectivity. The condensation can be also carried out in the absence of base and with sub-stoicheiometric amounts of the Lewis acid. The possible mechanisms of the process are discussed.

引用

页码：2583 / 2590

页数：8

共 28 条

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