Elucidating the inosinome: global approaches to adenosine-to-inosine RNA editing

被引：76

作者：

Wulff, Bjorn-Erik ^{[1
]}

Sakurai, Masayuki ^{[1
]}

Nishikura, Kazuko ^{[1
]}

机构：

[1] Wistar Inst Anat & Biol, Philadelphia, PA 19104 USA

来源：

NATURE REVIEWS GENETICS | 2011年 / 12卷 / 02期

基金：

美国国家卫生研究院; 日本学术振兴会;

关键词：

HUMAN TRANSCRIPTOME; ADAR DEAMINASES; MESSENGER-RNA; SITES; BRAIN; IDENTIFICATION; EXPRESSION; TARGETS; BIOGENESIS; MICRORNAS;

D O I：

10.1038/nrg2915

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Catalysed by members of the adenosine deaminase acting on RNA (ADAR) family of enzymes, adenosine-to-inosine (A-to-I) editing converts adenosines in RNA molecules to inosines, which are functionally equivalent to guanosines. Recently, global approaches to studying this widely conserved phenomenon have emerged. The use of bioinformatics, high-throughput sequencing and other approaches has increased the number of known editing sites by several orders of magnitude, and we now have a greater understanding of the control and the biological significance of editing. This Progress article reviews some of these recent global studies and their results.

引用

页码：81 / 85

页数：5

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