Investigating the biological functions of DNA topoisomerases in eukaryotic cells

被引:304
作者
Nitiss, JL [1 ]
机构
[1] St Jude Childrens Res Hosp, Dept Mol Pharmacol, Memphis, TN 38105 USA
来源
BIOCHIMICA ET BIOPHYSICA ACTA-GENE STRUCTURE AND EXPRESSION | 1998年 / 1400卷 / 1-3期
关键词
topoisomerase; mitosis; gene disruption; transcription; chromosome condensation;
D O I
10.1016/S0167-4781(98)00128-6
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
DNA topoisomerases participate in nearly all events relating to DNA metabolism including replication, transcription, and chromosome segregation. Recent studies in eukaryotic cells have led to the discovery of several novel topoisomerases, and to new questions concerning the roles of these enzymes in cellular processes. Gene knockout studies are helping to delineate the roles of topoisomerases in mammalian cells, just as similar studies in yeast established paradigms concerning the functions of topoisomerases in lower eukaryotes. The application of new technologies for identifying interacting proteins has connected the studies on topoisomerases to other areas of human biology including genome stability and aging. These studies highlight the importance of understanding how topoisomerases participate in the normal processes of transcription, DNA replication, and genome stability. 0167-4781/98/$ - see front matter (C) 1998 Elsevier Science B.V. All rights reserved.
引用
收藏
页码:63 / 81
页数:19
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