Mesenchymal stem cells for acute lung injury: Preclinical evidence

被引：144

作者：

Matthay, Michael A. ^{[1
,2
,3
]}

Goolaerts, Arnaud ^{[4
]}

Howard, James P. ^{[5
]}

Lee, Jae Woo ^{[2
,6
]}

机构：

[1] Univ Calif San Francisco, Dept Med, San Francisco, CA 94143 USA

[2] Univ Calif San Francisco, Dept Anesthesia, San Francisco, CA 94143 USA

[3] Univ Calif San Francisco, Cardiovasc Res Inst, San Francisco, CA 94143 USA

[4] Univ Paris, Fac Bichat, INSERM, U773,CRB3, F-75252 Paris, France

[5] Univ Calif San Francisco, Dept Pediat, San Francisco, CA 94143 USA

[6] Univ Calif San Francisco, Cardiovasc Res Inst, San Francisco, CA 94143 USA

来源：

CRITICAL CARE MEDICINE | 2010年 / 38卷

关键词：

pulmonary edema; acute respiratory distress syndrome; sepsis; acute respiratory failure; BONE-MARROW; STROMAL CELLS; REPAIR; ENGRAFTMENT; PROTECT; HOST;

D O I：

10.1097/CCM.0b013e3181f1ff1d

中图分类号：

R4 [临床医学];

学科分类号：

100218 [急诊医学];

摘要：

Several experimental studies have suggested that mesenchymal stem cells may have value for the treatment of clinical disorders, including myocardial infarction, diabetes, acute renal failure, sepsis, and acute lung injury. In preclinical studies, mesenchymal stem cells have been effective in reducing lung injury from endotoxin, live bacteria, bleomycin, and hyperoxia. In some studies, the cultured medium from mesenchymal stem cells has been as effective as the mesenchymal stem cells themselves. Several paracrine mediators that can mediate the effect of mesenchymal stem cells have been identified, including interleukin-10, interleukin-1ra, keratinocyte growth factor, and prostaglandin E-2. Further preclinical studies are needed, as is planning for clinical trials for acute lung injury. (Crit Care Med 2010; 38[Suppl.]:S569-S573)

引用

页码：S569 / S573

页数：5

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