Synthesis of cyclic, multivalent Arg-Gly-Asp using sequential thiol-ene/thiol-yne photoreactions

被引：36

作者：

Aimetti, Alex A. ^{[1
]}

Feaver, Kristen R. ^{[1
]}

Anseth, Kristi S. ^{[1
,2
]}

机构：

[1] Univ Colorado, Dept Chem & Biol Engn, Boulder, CO 80309 USA

[2] Univ Colorado, Howard Hughes Med Inst, Boulder, CO 80309 USA

来源：

CHEMICAL COMMUNICATIONS | 2010年 / 46卷 / 31期

关键词：

CLICK CHEMISTRY; PEPTIDE DENDRIMERS; CYCLOADDITION; NETWORKS; DESIGN; SYSTEM;

D O I：

10.1039/c0cc01292k

中图分类号：

O6 [化学];

学科分类号：

070301 [无机化学];

摘要：

A unique method has been developed for the formation of multivalent cyclic peptides. This procedure exploits on-resin peptide cyclization using a photoinitiated thiol-ene click reaction and subsequent clustering using thiol-yne photochemistry. Both reactions utilize the sulfhydryl group on natural cysteine amino acids to participate in the thiol-mediated reactions.

引用

页码：5781 / 5783

页数：3

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