MicroRNAs: Potential biomarkers for cancer diagnosis, prognosis and targets for therapy

被引：406

作者：

Cho, William C. S. ^{[1
]}

机构：

[1] Queen Elizabeth Hosp, Dept Clin Oncol, Kowloon, Hong Kong, Peoples R China

来源：

INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY | 2010年 / 42卷 / 08期

关键词：

MicroRNA; Biomarker; Cancer; Diagnosis; Prognosis; Therapy; CHRONIC LYMPHOCYTIC-LEUKEMIA; BREAST-CANCER; DOWN-REGULATION; STEM-CELLS; HEPATOCELLULAR-CARCINOMA; COLORECTAL-CANCER; MIRNA EXPRESSION; PROSTATE-CANCER; BLADDER-CANCER; METASTASIS;

D O I：

10.1016/j.biocel.2009.12.014

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

MicroRNAs have a revolutionary impact on cancer research over recent years. They emerge as important players in tumorigenesis, leading to a paradigm shift in oncology. The widespread and comprehensive use of microRNA microarrays has enabled the identification of a number of microRNAs as potential biomarkers for cancer. It is encouraging to report that microRNAs have remarkable stability in both formalin-fixed tissue and blood. Many microRNAs have been identified to act as oncogenes, tumor suppressors, or even modulators of cancer stem cells and metastasis. Some studies not only reported the identified microRNA biomarkers, but also deciphered their target genes and the underlying mechanisms. The rapid discovery of many microRNA targets and their relevant pathways has contributed to the development of microRNA-based therapeutics, but the developing progress of antisense or siRNA drugs has been hampered by stability, specificity and delivery problems. This review summarizes the most significant and latest findings of original researches on microRNAs involvement in cancer, focusing on the potential of cancer-related mitroRNAs as biomarkers for diagnosis, prognosis and targets for therapy. (C) 2009 Elsevier Ltd. All rights reserved.

引用

页码：1273 / 1281

页数：9

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