Stereochemical diversity in chiral ligand design: Discovery and optimization of catalysts for the enantioselective addition of allylic halides to aldehydes

被引：75

作者：

Lee, JY ^{[1
]}

Miller, JJ ^{[1
]}

Hamilton, SS ^{[1
]}

Sigman, MS ^{[1
]}

机构：

[1] Univ Utah, Dept Chem, Salt Lake City, UT 84112 USA

来源：

ORGANIC LETTERS | 2005年 / 7卷 / 09期

关键词：

D O I：

10.1021/ol050528e

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

We have identified a new set of stereochemically diverse oxazoline ligands derived from simple amino acids that promote the Cr-catalyzed enantioselective addition of allylic halides to aldehydes in up to 95% ee. The Cr-catalyzed allylation using ligand 1d is rather insensitive to the nature of the allylic bromide (crotyl, allyl, and methallyl) in that > 90% ee is observed for all three bromides evaluated in the addition to benzaldehyde.

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页码：1837 / 1839

页数：3

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