OPINION Periodontitis in RA-the citrullinated enolase connection

被引：268

作者：

Lundberg, Karin ^{[1
]}

Wegner, Natalia ^{[1
]}

Yucel-Lindberg, Tulay ^{[2
]}

Venables, Patrick J. ^{[1
]}

机构：

[1] Univ London Imperial Coll Sci Technol & Med, Kennedy Inst Rheumatol, London W6 8LH, England

[2] Karolinska Inst, Dept Dent Med, SE-14104 Huddinge, Sweden

来源：

NATURE REVIEWS RHEUMATOLOGY | 2010年 / 6卷 / 12期

关键词：

RHEUMATOID-ARTHRITIS; PORPHYROMONAS-GINGIVALIS; ALPHA-ENOLASE; HLA DR4; DISEASE; ASSOCIATION; IDENTIFICATION; ETIOLOGY; ANTIBODY; AUTOIMMUNITY;

D O I：

10.1038/nrrheum.2010.139

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Autoimmunity in rheumatoid arthritis (RA) is characterized by an antibody response to citrullinated proteins. Two of the risk factors for RA-HLA-DRB1 shared epitope alleles and smoking-are also associated with periodontitis, which is largely, but not exclusively, caused by Porphyromonas gingivalis infection. Furthermore, RA and periodontitis have a similar pathophysiology, characterized by destructive inflammation. The citrullination of proteins by P. gingivalis and the subsequent generation of autoantigens that drive autoimmunity in RA represents a possible causative link between these two diseases. Antibodies directed towards the immunodominant epitope of human citrullinated a-enolase cross-react with a conserved sequence on citrullinated P. gingivalis enolase. On the basis of this cross-reactivity, in this Perspectives article we explore the hypothesis of molecular mimicry in the etiology of RA, with citrullinated enolase as the specific antigen involved.

引用

页码：727 / 730

页数：4

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