Hepatitis C virus transmission in a pediatric oncology ward:: Analysis of an outbreak and review of the literature

被引：25

作者：

Knöll, A

Helmig, M

Peters, O

Jilg, W

机构：

[1] Univ Regensburg, Inst Med Microbiol & Hyg, D-93053 Regensburg, Germany

[2] St Hedwig Childrens Hosp, Regensburg, Germany

来源：

LABORATORY INVESTIGATION | 2001年 / 81卷 / 03期

关键词：

D O I：

10.1038/labinvest.3780234

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Hospital-related hepatitis C virus (HCV) infections continue to occur even after the introduction of blood donor screening. We report an outbreak of HCV in nine patients of a pediatric oncology ward in 1996/1997. Sequencing of the hypervariable genomic region 1 (HVR1) of the E2/NS1 region showed near identity between HCV isolates from these patients as evidence for infection with the same virus. Despite a detailed and careful investigation, the source of infection and the mode of Virus transmission could not be established. Based on a review of the current literature about nosocomial HCV infection and HCV infection in children, hypotheses for possible means of transmission in this outbreak are discussed.

引用

页码：251 / 262

页数：12

共 127 条

[21] Surgeon infects patient with hepatitis C [J].