Isolation and characterization of new epothilone analogues from recombinant Myxococcus xanthus fermentations

被引：25

作者：

Starks, CM ^{[1
]}

Zhou, YQ ^{[1
]}

Liu, FH ^{[1
]}

Licari, PJ ^{[1
]}

机构：

[1] Kosan Biosci Inc, Hayward, CA 94545 USA

来源：

JOURNAL OF NATURAL PRODUCTS | 2003年 / 66卷 / 10期

关键词：

D O I：

10.1021/np030218+

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

Nine new epothilone analogues (6-8, 10, 11a, 11b, 12, 13, and 15) were isolated from fermentations of Myxococcus xanthus strains engineered with modified polyketide synthase genes. The epothilone structures were elucidated primarily through interpretation of 1D and 2D NMR data. 4-Desmethyl-10,11-didehydroepothilone D (6) displayed activity against several tumor cell lines, including a multi-drug-resistant cell line.

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页码：1313 / 1317

页数：5

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