Use of Raman spectroscopy as a tool for in situ monitoring of microwave-promoted reactions

被引：36

作者：

Leadbeater, Nicholas E. ^{[1
]}

Schmink, Jason R. ^{[1
]}

机构：

[1] Univ Connecticut, Dept Chem, Storrs, CT 06269 USA

来源：

NATURE PROTOCOLS | 2008年 / 3卷 / 01期

关键词：

D O I：

10.1038/nprot.2007.453

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

The progress of microwave-promoted reactions can be monitored by interfacing a Raman spectrometer with a scientific microwave unit. The apparatus is assembled from commercially available components. It is used in this protocol to follow the base-catalyzed reaction of salicylaldehyde with ethylacetoacetate to yield 3-acetylcoumarin. It is possible to watch the reaction spectroscopically in real time, determine when it reaches completion and thus use it as a tool for rapid reaction optimization.

引用

页码：1 / 7

页数：7

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