Serological association of measles virus and human herpesvirus-6 with brain autoantibodies in autism

被引:104
作者
Singh, VK [1 ]
Lin, SX [1 ]
Yang, VC [1 ]
机构
[1] Univ Michigan, Coll Pharm, Ann Arbor, MI 48109 USA
来源
CLINICAL IMMUNOLOGY AND IMMUNOPATHOLOGY | 1998年 / 89卷 / 01期
关键词
autism; autoimmunity; autoantibodies; developmental disorders; virus serology; measles; HHV-6; child behavior; brain disorders;
D O I
10.1006/clin.1998.4588
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
Considering an autoimmunity and autism connection, brain autoantibodies to myelin basic protein (anti-MBP) and neuron-axon filament protein (anti-NAFP) have been found in autistic children. In this current study, we examined associations between virus serology and autoantibody by simultaneous analysis of measles virus antibody (measles-IgG), human herpesvirus-6 antibody (HHV-6-IgG), anti-MBP, and anti-NAFP, We found that measles-IgG and HHV-6-IgG titers were moderately higher in autistic children but they did not significantly differ from normal controls, Moreover, we found that a vast majority of virus serology-positive autistic sera was also positive for brain autoantibody: (i) 90% of measles-IgG-positive autistic sera was also positive for anti-MBP; (ii) 73% of measles-IgG-positive autistic sera was also positive for anti-NAFP; (iii) 84% of HHV-6-IgG-positive autistic sera was also positive for anti-MBP; and (iv) 72% of HHV-6-IgG-positive autistic sera was also positive for anti-NAFP, This study is the first to report an association between virus serology and brain autoantibody in autism; it supports the hypothesis that a virus-induced autoimmune response may play a causal role in autism. (C) 1998 Academic Press.
引用
收藏
页码:105 / 108
页数:4
相关论文
共 21 条
[1]   PLAQUE-ASSOCIATED EXPRESSION OF HUMAN HERPESVIRUS-6 IN MULTIPLE-SCLEROSIS [J].
CHALLONER, PB ;
SMITH, KT ;
PARKER, JD ;
MACLEOD, DL ;
COULTER, SN ;
ROSE, TM ;
SCHULTZ, ER ;
BENNETT, JL ;
GARBER, RL ;
CHANG, M ;
SCHAD, PA ;
SEWART, PM ;
NOWINSKI, RC ;
BROWN, JP ;
BURMER, GC .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1995, 92 (16) :7440-7444
[2]   BEHAVIORAL CONSEQUENCES OF CONGENITAL-RUBELLA [J].
CHESS, S ;
FERNANDEZ, P ;
KORN, S .
JOURNAL OF PEDIATRICS, 1978, 93 (04) :699-703
[3]   Dialysable lymphocyte extract (DLyE) in infantile onset autism: A pilot study. [J].
Fudenberg, HH .
BIOTHERAPY, 1996, 9 (1-3) :143-147
[4]   MOLECULAR MIMICRY IN VIRUS-INFECTION - CROSSREACTION OF MEASLES-VIRUS PHOSPHOPROTEIN OR OF HERPES-SIMPLEX VIRUS PROTEIN WITH HUMAN INTERMEDIATE FILAMENTS [J].
FUJINAMI, RS ;
OLDSTONE, MBA ;
WROBLEWSKA, Z ;
FRANKEL, ME ;
KOPROWSKI, H .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA-BIOLOGICAL SCIENCES, 1983, 80 (08) :2346-2350
[5]   Dysregulated immune system in children with autism: Beneficial effects of intravenous immune globulin on autistic characteristics [J].
Gupta, S ;
Aggarwal, S ;
Heads, C .
JOURNAL OF AUTISM AND DEVELOPMENTAL DISORDERS, 1996, 26 (04) :439-452
[6]   AUTISM AS ONE OF SEVERAL DISABILITIES IN 2 CHILDREN WITH CONGENITAL CYTOMEGALOVIRUS-INFECTION [J].
IVARSSON, SA ;
BJERRE, I ;
VEGFORS, P ;
AHLFORS, K .
NEUROPEDIATRICS, 1990, 21 (02) :102-103
[7]   MEASLES ENCEPHALOMYELITIS - CLINICAL AND IMMUNOLOGICAL STUDIES [J].
JOHNSON, RT ;
GRIFFIN, DE ;
HIRSCH, RL ;
WOLINSKY, JS ;
ROEDENBECK, S ;
DESORIANO, IL ;
VAISBERG, A .
NEW ENGLAND JOURNAL OF MEDICINE, 1984, 310 (03) :137-141
[8]   HUMAN HERPESVIRUS-6 - CLINICAL IMPLICATIONS OF A RECENTLY DISCOVERED, UBIQUITOUS AGENT [J].
LEACH, CT ;
SUMAYA, CV ;
BROWN, NA .
JOURNAL OF PEDIATRICS, 1992, 121 (02) :173-181
[9]   TH1 AND TH2 CD4(+) T-CELLS IN THE PATHOGENESIS OF ORGAN-SPECIFIC AUTOIMMUNE-DISEASES [J].
LIBLAU, RS ;
SINGER, SM ;
MCDEVITT, HO .
IMMUNOLOGY TODAY, 1995, 16 (01) :34-38
[10]  
MENAGE P, 1992, BRAIN DYSFUNCT, V5, P326