The effect of age on the expression of Interleukin-2

被引：77

作者：

Pahlavani, MA ^{[1
]}

Richardson, A ^{[1
]}

机构：

[1] UNIV TEXAS, HLTH SCI CTR, DEPT PHYSIOL, SAN ANTONIO, TX 78284 USA

来源：

MECHANISMS OF AGEING AND DEVELOPMENT | 1996年 / 89卷 / 03期

关键词：

aging; immune system; Interleukin-2; transcription; transcription factors;

D O I：

10.1016/0047-6374(96)01725-3

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Interleukin-2 (IL-2) is a growth promoting cytokine that has received a great deal of attention over the past decade with respect to aging and cancer. It is produced primarily by helper T cells and regulates the growth and function of various cells that are involved in cellular and humoral immunity. The expression of IL-2 has been found to decrease with age in humans and rodents. The decline in IL-2 production has been shown to parallel the age-related decrease in immunologic function. Several studies indicate that treatment of lymphocytes from old subjects with exogenous IL-2 or infusion of IL-2 into old animals partially or completely restores some of the immune functions that decline with age. The age-related decline in IL-2 production has been shown to arise from a decline in IL-2 transcription, and a recent study suggests that the transcription factor NFAT (nuclear factor of activated T cells) may play a role in the decline in IL-2 transcription.

引用

页码：125 / 154

页数：30

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