A new regioselective synthesis of 3-substituted furan-2(5H)-ones by palladium-catalysed reductive carbonylation of alk-1-ynes

被引：34

作者：

Gabriele, B ^{[1
]}

Salerno, G

Costa, M

Chiusoli, GP

机构：

[1] Univ Calabria, Dipartimento Chim, I-87030 Arcavacata, Italy

[2] Univ Parma, Dipartimento Chim Organ & Ind, I-43100 Parma, Italy

来源：

TETRAHEDRON LETTERS | 1999年 / 40卷 / 05期

关键词：

alkynes; carbonylation; furanones; palladium;

D O I：

10.1016/S0040-4039(98)02464-2

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

3-Alkyl- or 3-aryl-substituted furan-2(5H)-ones are obtained directly in fair yields by reductive carbonylation of alk-1-ynes in the presence of catalytic amounts of palladium iodide in conjunction with potassium iodide (10 eq.) and water (200 eq.). Simultaneous oxidation of CO to CO2 accounts for the stoichiometry of the process. Reactions are carried gut in dioxane under mild conditions (80 degrees C and 10 atm of carbon monoxide). (C) 1999 Elsevier Science Ltd. All rights reserved.

引用

页码：989 / 990

页数：2

共 4 条

[1] COUPLING OF OXIDATIVE AND REDUCTIVE PROCESSES - CATALYTIC CARBONYLATION OF ACETALS OF PROP-2-YNAL [J].