Increased serum concentrations of carbohydrate-deficient transferrin (CDT) in patients with cystic fibrosis

被引：23

作者：

Larsson, A ^{[1
]}

Flodin, M ^{[1
]}

Kollberg, H ^{[1
]}

机构：

[1] Univ Uppsala Hosp, Dept Clin Chem, S-75185 Uppsala, Sweden

来源：

UPSALA JOURNAL OF MEDICAL SCIENCES | 1998年 / 103卷 / 03期

关键词：

D O I：

10.3109/03009739809178952

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Carbohydrate-deficient transferrin (CDT) has been reported to be one of the best laboratory markers in serum (S) for detection of alcohol abuse. We have studied S-CDT values in cystic fibrosis (CF) patients and show that CF patients have increased S-CDT values without high alcohol consumption. CF patients have abnormalities in their protein glycosylation and sialylation, which may explain the increased S-CDT values.

引用

页码：231 / 236

页数：6

共 17 条

[1] DEFECTIVE ACIDIFICATION OF INTRACELLULAR ORGANELLES IN CYSTIC-FIBROSIS [J].

BARASCH, J ;

KISS, B ;

PRINCE, A ;

SAIMAN, L ;

GRUENERT, D ;

ALAWQATI, Q .

NATURE, 1991, 352 (6330) :70-73

[2] INCREASED SULFATION OF GLYCOCONJUGATES BY CULTURED NASAL EPITHELIAL-CELLS FROM PATIENTS WITH CYSTIC-FIBROSIS [J].

CHENG, PW ;

BOAT, TF ;

CRANFILL, K ;

YANKASKAS, JR ;

BOUCHER, RC .

JOURNAL OF CLINICAL INVESTIGATION, 1989, 84 (01) :68-72

[3]

CHOSH P, 1997, ALCOHOLISM CLIN EXP, V21, P76

[4] HETEROLOGOUS EXPRESSION OF DELTA-F508 CFTR RESULTS IN DECREASED SIALYLATION OF MEMBRANE GLYCOCONJUGATES [J].

DOSANJH, A ;

LENCER, W ;

BROWN, D ;

AUSIELLO, DA ;

STOW, JL .

AMERICAN JOURNAL OF PHYSIOLOGY, 1994, 266 (02) :C360-C366

[5] GLYCAN MICROHETEROGENEITY OF ALPHA-1-ANTITRYPSIN IN SERUM AND MECONIUM FROM NORMAL AND CYSTIC-FIBROSIS PATIENTS BY CROSSED IMMUNOAFFINOELECTROPHORESIS WITH DIFFERENT LECTINS (CON A, LCA, WGA) [J].

DUTHEL, S ;

REVOL, A .

CLINICA CHIMICA ACTA, 1993, 215 (02) :173-187

[6] ENZYMES AND CIRCULATING PROTEINS AS MARKERS OF ALCOHOL-ABUSE [J].

GOLDBERG, DM ;

KAPUR, BM .

CLINICA CHIMICA ACTA, 1994, 226 (02) :191-209

[7]

JEPPSSON JO, 1993, CLIN CHEM, V39, P2115

[8] Transferrin isoform distribution:: Gender and alcohol consumption [J].

Märtensson, O ;

Härlin, A ;

Brandt, R ;

Seppä, K ;

Sillanaukee, P .

ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH, 1997, 21 (09) :1710-1715

[9] Cystic fibrosis [J].

Rosenstein, BJ ;

Zeitlin, PL .

LANCET, 1998, 351 (9098) :277-282

[10]

Schellenberg F, 1996, CLIN CHEM, V42, P551

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