F2-isoprostanes as markers of oxidative stress in vivo:: An overview

被引：243

作者：

Milne, GL

Musiek, ES

Morrow, JD

机构：

[1] Vanderbilt Univ, Sch Med, Dept Med, Nashville, TN 37232 USA

[2] Vanderbilt Univ, Sch Med, Dept Pharmacol, Nashville, TN 37232 USA

来源：

BIOMARKERS | 2005年 / 10卷

关键词：

Lipid peroxidation; eicosanoid; isoprostane; lipid; oxidant stress; oxidative stress;

D O I：

10.1080/13547500500216546

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

The isoprostanes are a unique series of prostaglandin-like compounds formed in vivo via a nonenzymatic mechanism involving the free radical-initiated peroxidation of arachidonic acid. This article summarizes selected aspects regarding current knowledge of these compounds and their value as markers of oxidative injury. Novel aspects related to the biochemistry of isoprostane formation are discussed and methods by which these compounds can be analysed and quantified are summarized. A considerable portion of this article examines the utility of F-2-isoprostanes as markers of oxidant injury in vivo. Numerous studies carried out over the past decade have shown that these compounds are extremely accurate measures of lipid peroxidation and have illuminated the role of oxidant injury in a number of human diseases including atherosclerosis, Alzheimer's disease and pulmonary disorders.

引用

页码：S10 / S23

页数：14

共 81 条

[1]

Aleynik SI, 1998, ALCOHOL CLIN EXP RES, V22, P192, DOI 10.1111/j.1530-0277.1998.tb03637.x

[2] Raised levels of F2-isoprostanes and prostaglandin F2α in different rheumatic diseases [J].