Natural products as a gold mine for selective matrix metalloproteinases inhibitors

被引：50

作者：

Wang, Liyan ^{[2
]}

Li, Xi ^{[2
]}

Zhang, Shoude ^{[1
]}

Lu, Weiqiang ^{[2
]}

Liao, Sha ^{[2
]}

Liu, Xiaofeng ^{[2
]}

Shan, Lei ^{[3
]}

Shen, Xu ^{[2
]}

Jiang, Hualiang ^{[2
]}

Zhang, Weidong ^{[1
,3
]}

Huang, Jin ^{[2
]}

Li, Honglin ^{[2
]}

机构：

[1] Shanghai Jiao Tong Univ, Sch Pharm, Shanghai 200240, Peoples R China

[2] E China Univ Sci & Technol, Shanghai Key Lab New Drug Design, State Key Lab Bioreactor Engn, Sch Pharm, Shanghai 200237, Peoples R China

[3] Second Mil Med Univ, Dept Phytochem, Sch Pharm, Shanghai 200433, Peoples R China

来源：

BIOORGANIC & MEDICINAL CHEMISTRY | 2012年 / 20卷 / 13期

基金：

中国国家自然科学基金; 高等学校博士学科点专项科研基金;

关键词：

Matrix metalloproteinases; Virtual screening; Natural product; Anticancer agent; DISCOVERY; COMPOUND; PROTEIN; AE-941; DESIGN; ROLES; DRUGS;

D O I：

10.1016/j.bmc.2012.04.063

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

070307 [化学生物学]; 071010 [生物化学与分子生物学];

摘要：

Nineteen natural compounds with diverse structures are identified as potential MMPIs using structure-based virtual screening from 4000 natural products. Hydroxycinnamic acid or analogs of natural products are important for potent inhibitory and selectivity against MMPs, and the solvent effect in the S10 pocket can affect the hydrophobic interactions and hydrogen bonds between MMPIs and MMPS, making MMPIs exhibit certain selectivity for a specific MMP isoenzyme. Furthermore, compound 5 can reduce the expression of both MMP-2 and active-MMP-9, and suppress the migration of MDA-MB-231 tumor cell in a wound healing assay, which may be further developed as an anticancer agent. (C) 2012 Elsevier Ltd. All rights reserved.

引用

页码：4164 / 4171

页数：8

共 24 条

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[2]

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[3]

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