H/D-exchange reactions with hydride-activated catalysts

被引：27

作者：

Derdau, Volker ^{[1
]}

Atzrodt, Jens ^{[1
]}

Holla, Wolfgang ^{[1
]}

机构：

[1] Sanofi Aventis Deutsch GmbH, GMPK, D-65926 Frankfurt, Germany

来源：

JOURNAL OF LABELLED COMPOUNDS & RADIOPHARMACEUTICALS | 2007年 / 50卷 / 5-6期

关键词：

deuterium; palladium; rhodium; heterogeneous catalysis; alkaloids; microwave;

D O I：

10.1002/jlcr.1209

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

A safe, user friendly and efficient method to provide high deuterium incorporation into a variety of organic substrates was developed. Systematic screening of catalysts and activators revealed that the activation of the Pd- or Rh-catalyst by NaBD4 is essential for the H/D exchange. The feasibility has been demonstrated by the successful application of this method to bi- and tricyclic aromatic compounds as well as chiral natural products like dextrorphan or drugs like formoterol. (c) Copyright 2007 John Wiley & Sons, Ltd.

引用

页码：295 / 299

页数：5

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