C-H/C-D exchange reactions of aromatic compounds in D2O with NaBD4-activated catalysts

被引：38

作者：

Derdau, Volker ^{[1
]}

Atzrodt, Jens ^{[1
]}

机构：

[1] Sanofi Aventis Deutschland GmbH, GMPK, Isotope Chem & Metabolite Synth Frankfurt, D-35926 Frankfurt Hochst, Germany

来源：

SYNLETT | 2006年 / 12期

关键词：

deuterium; palladium; rhodium; heterogenous catalysis; alkaloids;

D O I：

10.1055/s-2006-947342

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A safe and efficient method for catalytic H/D exchange to provide high deuterium incorporation into a variety of aromatic substrates was developed. Systematic screening of the catalyst and activator revealed that the essential activation of the Pd or Rh catalyst could be achieved under safe and user friendly conditions. The application of this simple catalytic method for the deuteration of bi- and tricyclic aromatic compounds and chiral natural products was investigated.

引用

页码：1918 / 1922

页数：5

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