Microwave-enhanced hydrogen isotope exchange studies of heterocyclic compounds

被引：21

作者：

Anto, S ^{[1
]}

Getvoldsen, GS

Harding, JR

Jones, JR

Lu, SY

Russell, JC

机构：

[1] Univ Surrey, Sch Phys & Chem, Dept Chem, Guildford GU2 7XH, Surrey, England

[2] AstraZeneca, Macclesfield SK10 4TG, Cheshire, England

[3] Biocompatibles Ltd, Farnham GU9 8QL, Surrey, England

来源：

JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 2 | 2000年 / 11期

关键词：

D O I：

10.1039/b005724j

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The microwave-enhanced hydrogen-deuterium exchange reaction of a number of nitrogen-containing heterocyclic compounds has been achieved extremely rapidly (< 20 min) via their hydrochloride salts, whilst the corresponding Raney-nickel catalysed reactions of indole and N-methylindole are also complete in a similar time interval. Furthermore, the pattern of labelling in the latter reaction depends critically on the choice of solvent used.

引用

页码：2208 / 2211

页数：4

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