Aptamers are ready for the spotlight.

被引：22

作者：

Mukhopadhyay, R

机构：

来源：

ANALYTICAL CHEMISTRY | 2005年 / 77卷 / 05期

关键词：

D O I：

10.1021/ac053344m

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

Aptamers, 3-D structures of DNA or RNA that bind to a variety of targets, were first described in the early 1990s. Rajendrani Mukhopadhyay finds that since their discovery, the applications for these molecules have become widespread, ranging from drugs to proteomics chips. © 2005 American Chemical Society.

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页码：114A / 118A

页数：5

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共 9 条

[1] Retention and separation of adenosine and analogues by affinity chromatography with an aptamer stationary phase [J].

Deng, Q ;

German, I ;

Buchanan, D ;

Kennedy, RT .

ANALYTICAL CHEMISTRY, 2001, 73 (22) :5415-5421

[2] Aptamer-enhanced laser desorption/ionization for affinity mass spectrometry [J].

Dick, LW ;

McGown, LB .

ANALYTICAL CHEMISTRY, 2004, 76 (11) :3037-3041

[3] INVITRO SELECTION OF RNA MOLECULES THAT BIND SPECIFIC LIGANDS [J].

ELLINGTON, AD ;

SZOSTAK, JW .

NATURE, 1990, 346 (6287) :818-822

[4] Riboswitches control fundamental biochemical pathways in Bacillus subtilis and other bacteria [J].

Mandal, M ;

Boese, B ;

Barrick, JE ;

Winkler, WC ;

Breaker, RR .

CELL, 2003, 113 (05) :577-586

[5] A glycine-dependent riboswitch that uses cooperative binding to control gene expression [J].

Mandal, M ;

Lee, M ;

Barrick, JE ;

Weinberg, Z ;

Emilsson, GM ;

Ruzzo, WL ;

Breaker, RR .

SCIENCE, 2004, 306 (5694) :275-279

[6] THE NUCLEIC-ACID LIGAND - A NEW TOOL FOR MOLECULAR RECOGNITION [J].

MCGOWN, LB ;

JOSEPH, MJ ;

PITNER, JB ;

VONK, GP ;

LINN, CP .

ANALYTICAL CHEMISTRY, 1995, 67 (21) :A663-A668

[7] Antidote-mediated control of an anticoagulant aptamer in vivo [J].

Rusconi, CP ;

Roberts, JD ;

Pitoc, GA ;

Nimjee, SM ;

White, RR ;

Quick, G ;

Scardino, E ;

Fay, WP ;

Sullenger, BA .

NATURE BIOTECHNOLOGY, 2004, 22 (11) :1423-1428

[8] Micromechanical detection of proteins using aptamer-based receptor molecules [J].

Savran, CA ;

Knudsen, SM ;

Ellington, AD ;

Manalis, SR .

ANALYTICAL CHEMISTRY, 2004, 76 (11) :3194-3198

[9] SYSTEMATIC EVOLUTION OF LIGANDS BY EXPONENTIAL ENRICHMENT - RNA LIGANDS TO BACTERIOPHAGE-T4 DNA-POLYMERASE [J].

TUERK, C ;

GOLD, L .

SCIENCE, 1990, 249 (4968) :505-510