New insights for pursuing high relaxivity MRI agents from modelling the binding interaction of GdIII chelates to HSA

被引：35

作者：

Aime, S

Gianolio, E

Longo, D

Pagliarin, R

Lovazzano, C

Sisti, M

机构：

[1] Univ Turin, Dipartimento Chim, IFM, I-10125 Turin, Italy

[2] Univ Turin, Ctr Mol Imaging, I-10125 Turin, Italy

[3] Univ Milan, Dipartimento Chim Organ & Ind, I-20133 Milan, Italy

[4] Univ Studi Insubria, Dipartimento Sci Chim & Ambientali, I-22100 Como, Italy

来源：

CHEMBIOCHEM | 2005年 / 6卷 / 05期

关键词：

albumin; chelates; drug delivery; high relaxivity; imaging agents; molecular modeling;

D O I：

10.1002/cbic.200400364

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

This work is aimed at obtaining new insights into the design of novel Gd chelates that form high-affinity adducts with HSA. Two new Gd complexes that differ in the size of the hydrophobic moiety responsible for the interaction with the protein have been synthesised. It was shown that the two complexes protrude to a different extent from the surface of the protein (see picture), and this difference has an effect on the exchange of the coordinated water molecule.

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页码：818 / +

页数：4

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