The effect of a component of tea (Camellia sinensis) on methicillin resistance, PBP2′ synthesis, and β-lactamase production in Staphylococcus aureus

被引：102

作者：

Yam, TS ^{[1
]}

Hamilton-Miller, JMT ^{[1
]}

Shah, S ^{[1
]}

机构：

[1] Royal Free Hosp, Sch Med, Dept Med Microbiol, London NW3 2QG, England

来源：

JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY | 1998年 / 42卷 / 02期

关键词：

D O I：

10.1093/jac/42.2.211

中图分类号：

R51 [传染病];

学科分类号：

100401 ;

摘要：

Extracts of tea (Camellia sinensis) can reverse methicillin resistance in methicillin-resistant Staphylococcus aureus (MRSA) and also, to some extent, penicillin resistance in beta-lactamase-producing S. aureus. These phenomena are explained by prevention of PBP2' synthesis and inhibition of secretion of P-lactamase, respectively. Synergy between beta-lactams and tea extracts were demonstrated by disc diffusion, chequerboard titration and growth curves. Partition chromatography of an extract of green tea on Sephadex LH-20 yielded several fractions, one of which contained a virtually pure compound that showed the above-mentioned activities, at concentrations above about 2 mg/L. The observed activities are novel and distinct from the previously reported direct antibacterial activity of tea extracts. Prevention of PBP2' synthesis offers an interesting possible new approach for the treatment of infections caused by MRSA.

引用

页码：211 / 216

页数：6

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