Pattern of apolipoprotein D immunoreactivity in human brain

被引：61

作者：

Navarro, A ^{[1
]}

Tolivia, J ^{[1
]}

Astudillo, A ^{[1
]}

del Valle, E ^{[1
]}

机构：

[1] Univ Oviedo, Dept Morfol & Biol Celular, Fac Biol & Med, E-33006 Oviedo, Spain

来源：

NEUROSCIENCE LETTERS | 1998年 / 254卷 / 01期

关键词：

apolipoprotein D; immunocytochemistry; human; nervous system;

D O I：

10.1016/S0304-3940(98)00639-9

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Presence of intracytoplasmatic apolipoprotein D (apo D), a lipophilic ligand transporter, was investigated in normal human brains between 20 and 55 years, using an anti-human apolipoprotein D antibody and extravidin-biotin-enhanced immunohistochemistry. Apo D immunoreactivity was found in neuroglial cells of white matter in all sampled brain regions studied but also in pial cells and perivascular cells. Immunoreactive neurons do not present a uniform pattern throughout the gray matter. The pens and the brainstem show a high immunoreactivity for apo D in several nuclei (olivary, arciforme, cuneado, raphe). In the cerebellum the immunoreactivity appears in some neurons of the Purkinje layer. Finally in the cerebral cortex apo D positive neurons were not observed. These results suggest that apo D role may vary depending of cellular synthesis or location. (C) 1998 Elsevier Science Ireland Ltd. All rights reserved.

引用

页码：17 / 20

页数：4

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