The multifaceted role of Notch in cardiac development and disease

被引：234

作者：

High, Frances A. ^{[1
]}

Epstein, Jonathan A. ^{[1
]}

机构：

[1] Univ Penn, Dept Cell & Dev Biol, Philadelphia, PA 19104 USA

来源：

NATURE REVIEWS GENETICS | 2008年 / 9卷 / 01期

关键词：

D O I：

10.1038/nrg2279

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Notch receptors and their cognate ligands transduce crucial signals between cells in various tissues, and have been conserved across millions of years of evolution. Mutations in Notch signalling components result in congenital heart defects in humans and mice, demonstrating an essential role for Notch in cardiovascular development. The results of recent experiments implicate this signalling pathway in many stages of heart development, and provide mechanistic insight into the vital functions of Notch in the aetiology of several common forms of paediatric and adult cardiac disease.

引用

页码：49 / 61

页数：13

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