Advanced screening assays to rapidly identify solubility-enhancing formulations: High-throughput, miniaturization and automation

被引：50

作者：

Dai, Wei-Guo ^{[1
]}

Pollock-Dove, Crystal ^{[1
]}

Dong, Liang C. ^{[1
]}

Li, Shu ^{[1
]}

机构：

[1] ALZA Corp, Mountain View, CA 94039 USA

来源：

ADVANCED DRUG DELIVERY REVIEWS | 2008年 / 60卷 / 06期

关键词：

screening assay; formulation; high-throughput; miniaturization; automation; solubility;

D O I：

10.1016/j.addr.2007.10.017

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Development of solubility-enhancing formulations for poorly water-soluble compounds always poses a challenge. Conventional formulation screening assays are potentially time-consuming and labor-intensive and, moreover, require a large amount of a compound; they are not ideal when compound availability and testing time are limited. In recent years, in-vitro screening assays that are rapid, inexpensive, minimally labor-intensive, and require only small quantities of a compound have become available. These advanced assays allow high-throughput automation, miniaturization, and parallel processing, thereby enabling scientists to rapidly identify solubility-enhancing formulations with milligram or sub-milligram quantities of an active pharmaceutical ingredient (API). This article reviews these assays for rapidly screening the aqueous solubility of lead Compounds and the solubility-enhancing formulations with limited quantities of API. (C) 2008 Published by Elsevier B.V.

引用

页码：657 / 672

页数：16

共 60 条

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