Single protein pores containing molecular adapters at high temperatures

Bearing the heat: Current has been measured from individual protein pores at temperatures approaching 100°C. The molecular adapter β-cyclodextrin (red) remains bound to the α-hemolysin pore at high temperatures and retains the ability to bind guest molecules (black). Recording current at high temperatures is likely to be important for the study of single-molecule chemistry and in the development of stochastic sensors. © 2005 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim.