Enantioselective synthesis of the trans-2,6-dialkylpiperidine alkaloids (2R,6R)-lupetidine and (2R,6R)-solenopsin A

被引：23

作者：

Amat, M ^{[1
]}

Hidalgo, J ^{[1
]}

Llor, N ^{[1
]}

Bosch, J ^{[1
]}

机构：

[1] Univ Barcelona, Fac Pharm, Organ Chem Lab, E-08028 Barcelona, Spain

来源：

TETRAHEDRON-ASYMMETRY | 1998年 / 9卷 / 14期

关键词：

D O I：

10.1016/S0957-4166(98)00249-3

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

The enantioselective synthesis of the trans-2,6-dialkylpiperidine alkaloids (2R,6R)-lupetidine and (2R,6R)solenopsin A from 6-methyl-2-piperidone 1 is described. The key step of this synthesis consists of the addition of a dialkylcopper derivative to the thioimidate salt 3 followed by sodium borohydride reduction of the resulting iminium salt. (C) 1998 Elsevier Science Ltd. All rights reserved.

引用

页码：2419 / 2422

页数：4

共 63 条

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