Molecular variants of hepatitis B virus

被引:17
作者
Carman, WF
机构
关键词
D O I
10.1016/S0272-2712(18)30277-4
中图分类号
R446 [实验室诊断]; R-33 [实验医学、医学实验];
学科分类号
1001 ;
摘要
Variation in the genome of hepatitis B virus has been associated with a number of clinical parameters, but there is a paucity of functional data to show a causal relationship. For example, variants of the core and X genes have been linked with the pathogenesis of chronic hepatitis, viral replication efficiency, and serologically negative infections, among other observations. Variants of the surface antigen are linked with infection after vaccination, infection of liver grafts in patients undergoing immunotherapy, and samples that react poorly in diagnostic assays.
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页码:407 / &
页数:23
相关论文
共 97 条
  • [81] ACTIVE HEPATITIS-B VIRUS-REPLICATION IN THE PRESENCE OF ANTI-HBE IS ASSOCIATED WITH VIRAL VARIANTS CONTAINING AN INACTIVE PRE-C REGION
    TONG, SP
    LI, JS
    VITVITSKI, L
    TREPO, C
    [J]. VIROLOGY, 1990, 176 (02) : 596 - 603
  • [82] REPLICATION CAPACITIES OF NATURAL AND ARTIFICIAL PRECORE STOP CODON MUTANTS OF HEPATITIS-B VIRUS - RELEVANCE OF PREGENOME ENCAPSIDATION SIGNAL
    TONG, SP
    LI, JS
    VITVITSKI, L
    TREPO, C
    [J]. VIROLOGY, 1992, 191 (01) : 237 - 245
  • [83] EMERGENCE OF AND TAKEOVER BY HEPATITIS-B VIRUS (HBV) WITH REARRANGEMENTS IN THE PRE-S/S AND PRE-C/C GENES DURING CHRONIC HBV INFECTION
    TRAN, A
    KREMSDORF, D
    CAPEL, F
    HOUSSET, C
    DAUGUET, C
    PETIT, MA
    BRECHOT, C
    [J]. JOURNAL OF VIROLOGY, 1991, 65 (07) : 3566 - 3574
  • [84] Trautwein C., 1995, Journal of Hepatology, V23, P83
  • [85] A PRECORE-DEFECTIVE MUTANT OF HEPATITIS-B VIRUS ASSOCIATED WITH E ANTIGEN-NEGATIVE CHRONIC LIVER-DISEASE
    ULRICH, PP
    BHAT, RA
    KELLY, I
    BRUNETTO, MR
    BONINO, F
    VYAS, GN
    [J]. JOURNAL OF MEDICAL VIROLOGY, 1990, 32 (02) : 109 - 118
  • [86] SELECTIVE TRANSMISSION OF VARIANT GENOMES FROM MOTHER-TO-INFANT IN NEONATAL FULMINANT-HEPATITIS-B
    VONWEIZSACKER, F
    PULT, I
    GEISS, K
    WIRTH, S
    BLUM, HE
    [J]. HEPATOLOGY, 1995, 21 (01) : 8 - 13
  • [87] DETECTION OF PRE-C AND CORE REGION MUTANTS OF HEPATITIS-B VIRUS IN CHRONIC HEPATITIS-B VIRUS CARRIERS
    WAKITA, T
    KAKUMU, S
    SHIBATA, M
    YOSHIOKA, K
    ITO, Y
    SHINAGAWA, T
    ISHIKAWA, T
    TAKAYANAGI, M
    MORISHIMA, T
    [J]. JOURNAL OF CLINICAL INVESTIGATION, 1991, 88 (06) : 1793 - 1801
  • [88] MOLECULAR CHARACTERIZATION OF ENVELOPE ANTIGENIC VARIANTS OF HEPATITIS-B VIRUS FROM SPAIN
    WALLACE, LA
    ECHEVARRIA, JE
    ECHEVARRIA, JM
    CARMAN, WF
    [J]. JOURNAL OF INFECTIOUS DISEASES, 1994, 170 (05) : 1300 - 1303
  • [89] HEPATITIS-B-VIRUS-X PROTEIN INHIBITS P53 SEQUENCE-SPECIFIC DNA-BINDING, TRANSCRIPTIONAL ACTIVITY, AND ASSOCIATION WITH TRANSCRIPTION FACTOR ERCC3
    WANG, XW
    FORRESTER, K
    YEH, H
    FEITELSON, MA
    GU, JR
    HARRIS, CC
    [J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1994, 91 (06) : 2230 - 2234
  • [90] LOSS OF THE COMMON A DETERMINANT OF HEPATITIS-B SURFACE-ANTIGEN BY A VACCINE-INDUCED ESCAPE MUTANT
    WATERS, JA
    KENNEDY, M
    VOET, P
    HAUSER, P
    PETRE, J
    CARMAN, W
    THOMAS, HC
    [J]. JOURNAL OF CLINICAL INVESTIGATION, 1992, 90 (06) : 2543 - 2547